Endometriosis in a Rhesus Monkey.

Tsuneo Ito, Yoshiyuki Sakamaki, Etsuko Fujii, Yasuyuki Misawa, Masami Suzuki, Tetsuro Sugimoto
In: Journal of Toxicologic Pathology · 2001 · vol. 14(4) , pp. 313–315 · doi:10.1293/tox.14.313 · W2022011781
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

Spontaneous endometriosis was observed in a rhesus monkey, characterized by macroscopic thickening and nodules of the intestinal wall and omentum, with histopathological findings resembling endometrial glands and connective tissue.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This paper reports spontaneous endometriosis-like lesions in a 15-year-old female rhesus monkey, identified macroscopically as intestinal wall thickening involving the mesentery and gastrocolic omentum, with sporadic serosal nodules in the jejunum and ileum. Histology showed numerous glandular tubules with massive connective tissue in the serosa and subserosa, where the tubules were lined by mono- or multilayered epithelial cells bearing ciliary structures and embedded in mesh-like fibrous stroma with fibroblast-like cells and tortuous blood vessels. The authors specifically describe the glands and interstitial connective tissue as similar to uterine endometrium. This paper is centrally about endometriosis — it documents spontaneous endometriosis in a rhesus monkey with detailed macroscopic and histopathologic characterization.

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Abstract

Spontaneous endometriosis was found in a 15-year-old female rhesus monkey. Macroscopically, there was thickening of the intestinal wall, mesenterium, and the gastrocolic omentum. Sporadic nodules were noted in the serosa of the jejunum and ileum. Histopathologically, a large number of glandular tubules along with massive connective tissue was observed in the serosa and subserosa. The glandular tubules were covered with mono- or multilayered epithelial cells with ciliary structures protruding into the glandular lumen. The connective tissue was composed of mesh-like fiber, fibroblast-like cells, and tortuous blood vessels. The glandular tubules and the connective tissue were similar to the glands and interstitial tissue in the endometrium.
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JTP Forum Endometriosis in a Rhesus Monkey 2001 Volume 14 Issue 4 Pages 313 Details Abstract Spontaneous endometriosis was found in a 15-year-old female rhesus monkey. Macroscopically, there was thickening of the intestinal wall, mesenterium, and the gastrocolic omentum. Sporadic nodules were noted in the serosa of the jejunum and ileum. Histopathologically, a large number of glandular tubules along with massive connective tissue was observed in the serosa and subserosa. The glandular tubules were covered with mono- or multilayered epithelial cells with ciliary structures protruding into the glandular lumen. The connective tissue was composed of mesh-like fiber, fibroblast-like cells, and tortuous blood vessels. The glandular tubules and the connective tissue were similar to the glands and interstitial tissue in the endometrium. © 2001 The Japanese Society of Toxicologic Pathology Favorites & Alerts Recently viewed articles

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endometriosis

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