Endometriosis in Rhesus Monkeys

B S Lindberg, S. Lindberg, C Busch, Christer Busch
Upsala journal of medical sciences · 1984 · vol. 89(2) , pp. 129–134 · doi:10.3109/03009738409178472 · PMID:6464242 · W2018435651
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Endometriosis was found in five of six sacrificed Rhesus monkeys exhibiting symptoms like appetite loss and constipation, with the cause remaining unknown but likely due to retrograde menstruation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The paper reports that endometriosis was observed in 5 of 6 rhesus monkeys sacrificed for disease in a colony of 90, with clinical signs including loss of appetite, constipation, abdominal distension, and sometimes a palpable pelvic mass. At autopsy, the investigators found 300–500 ml of blood-stained abdominal fluid along with intestinal or pelvic endometriosis. The etiology was not determined, though the authors propose intraabdominal implantation of endometrial tissue via retrograde menstruation as the most probable explanation. The study is limited by the lack of information on why the lesion appears rarely in free-ranging colonies, including whether it relates to pregnancy frequency or to changes in menstruation frequency. This paper is centrally about endometriosis — it describes endometriosis occurrence, clinical presentation, and autopsy findings in rhesus monkeys and discusses a proposed mechanism.

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Abstract

Endometriosis was present in five out of six Rhesus monkeys who had to be sacrificed because of disease in a colony of 90. The monkeys lost appetite and became constipated. The abdomen was distended and often a pelvic mass could be palpated. At autopsy, 300-500 ml of blood-stained fluid was found in the abdomen together with intestinal or pelvic endometriosis. The ethiology of endometriosis in Rhesus monkeys is unknown. The most probable explanation is intraabdominal implantation of endometrial tissue through retrograde menstruation. The lesion is rare in animals in free ranging colonies. It is not known whether this is due to a higher frequency of pregnancies in animals with free access to matings or to its consequences, i.e. more infrequent menstruations.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Intestinal Neoplasms Monkey Diseases Ovarian Neoplasms Uterine Neoplasms Animals Endometriosis Endometriosis Female Intestinal Neoplasms Intestinal Neoplasms Intestines Intestines Macaca mulatta Monkey Diseases Ovarian Neoplasms Ovarian Neoplasms Ovary Ovary Uterine Neoplasms

Citation neighborhood

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References (10)

Cited by (10)

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