Acute Abdominal Distension Due to Disseminated Peritoneal Neoplasia in a Rhesus Macaque (Macaca mulatta)

Asher JL, Jennifer L. Asher, Barnett GJ, Grace J Barnett, Caroline J. Zeiss, Zeiss CJ
Comparative medicine · 2018 · vol. 68(5) , pp. 403–410 · doi:10.30802/aalas-cm-17-000112 · PMID:30139414 · PMC6200034 · W2888174841
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This report details a rhesus macaque with acute abdominal distension caused by peritoneal neoplasia, diagnosed as endometrial stromal sarcoma arising from endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The paper reports clinical, radiographic, and pathological findings in a female rhesus macaque with acute abdominal distension and tympany, including severe colonic distension on imaging and widespread peritoneal adhesions seen at laparotomy. Histopathology showed extensive entrapment of gastrointestinal and reproductive tracts by serosal fibrovascular proliferative tissue containing foci of endometriosis, and immunohistochemistry supported a diagnosis of endometrial stromal sarcoma via CD10, Wilms tumor 1, estrogen receptor, and progesterone receptor expression while excluding other marker-defined differentials. The authors note that in humans this uncommon neoplasm can arise from sites of endometriosis and present as intestinal obstruction, paralleling the macaque’s presentation. This paper is centrally about endometriosis—specifically endometriosis foci within disseminated peritoneal tissue associated with endometrial stromal sarcoma causing acute intestinal obstruction–like distension.

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Abstract

This report describes the clinical, radiographic, and pathologic findings in a female rhesus macaque that presented with acute abdominal distension and tympany. The macaque was euthanized after evidence of severe colonic distension on radiography and observation of widespread peritoneal adhesions on exploratory laparotomy. Gross and histopathologic evaluation revealed extensive entrapment of gastrointestinal and reproductive tracts by serosal fibrovascular proliferative tissue containing foci of endometriosis. The diagnosis of endometrial stromal sarcoma was supported by expression of CD10, Wilm tumor 1, estrogen receptor, and progesterone receptor and failure to express immunohistochemical markers characteristic of a range of differential diagnoses. In humans, this relatively uncommon neoplasm can arise from sites of endometriosis and often presents clinically as intestinal obstruction, similar to the presentation in this macaque.
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This report describes the clinical, radiographic, and pathologic findings in a female rhesus macaque that presented with acute abdominal distension and tympany. The macaque was euthanized after evidence of severe colonic distension on radiography and observation of widespread peritoneal adhesions on exploratory laparotomy. Gross and histopathologic evaluation revealed extensive entrapment of gastrointestinal and reproductive tracts by serosal fibrovascular proliferative tissue containing foci of endometriosis. The diagnosis of endometrial stromal sarcoma was supported by expression of CD10, Wilm tumor 1, estrogen receptor, and progesterone receptor and failure to express immunohistochemical markers characteristic of a range of differential diagnoses. In humans, this relatively uncommon neoplasm can arise from sites of endometriosis and often presents clinically as intestinal obstruction, similar to the presentation in this macaque. Editorial Type: research-article | Online Publication Date: 01 Oct 2018 Acute Abdominal Distension Due to Disseminated Peritoneal Neoplasia in a Rhesus Macaque (Macaca mulatta) Acute Abdominal Distension Due to Disseminated Peritoneal Neoplasia in a Rhesus Macaque (Macaca mulatta) Full access Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, USA Search for other papers by Jennifer L Asher in Comparative Medicine Resources, Rutgers University, New Brunswick, New Jersey, USA Search for other papers by Grace J Barnett in Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, USA. [email protected] Search for other papers by Caroline J Zeiss in Article Category: Research Article Page Range: 403 – 410 Copyright: 2018

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Condition tags

endometriosis

MeSH descriptors

Macaca mulatta Monkey Diseases Peritoneal Neoplasms Animals Diagnosis, Differential Endometriosis Endometriosis Endometriosis Female Immunohistochemistry Monkey Diseases Monkey Diseases Monkey Diseases Peritoneal Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms Tissue Adhesions

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