Acute Abdominal Distension Due to Disseminated Peritoneal Neoplasia in a Rhesus Macaque (Macaca mulatta)

Jennifer L Asher, Grace J Barnett, Caroline J Zeiss
Comparative medicine · 2018 · vol. 68(5) , pp. 403–410 · doi:10.30802/aalas-cm-17-000112 · PMID:30139414 · PMC6200034 · W2888174841
article OA: closed CC0 ⤵ 1 in-corpus citation
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This report details a rhesus macaque with acute abdominal distension caused by peritoneal neoplasia, diagnosed as endometrial stromal sarcoma arising from endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The paper reports clinical, radiographic, and pathological findings in a female rhesus macaque with acute abdominal distension and tympany, including severe colonic distension on imaging and widespread peritoneal adhesions seen at laparotomy. Histopathology showed extensive entrapment of gastrointestinal and reproductive tracts by serosal fibrovascular proliferative tissue containing foci of endometriosis, and immunohistochemistry supported a diagnosis of endometrial stromal sarcoma via CD10, Wilms tumor 1, estrogen receptor, and progesterone receptor expression while excluding other marker-defined differentials. The authors note that in humans this uncommon neoplasm can arise from sites of endometriosis and present as intestinal obstruction, paralleling the macaque’s presentation. This paper is centrally about endometriosis—specifically endometriosis foci within disseminated peritoneal tissue associated with endometrial stromal sarcoma causing acute intestinal obstruction–like distension.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

This report describes the clinical, radiographic, and pathologic findings in a female rhesus macaque that presented with acute abdominal distension and tympany. The macaque was euthanized after evidence of severe colonic distension on radiography and observation of widespread peritoneal adhesions on exploratory laparotomy. Gross and histopathologic evaluation revealed extensive entrapment of gastrointestinal and reproductive tracts by serosal fibrovascular proliferative tissue containing foci of endometriosis. The diagnosis of endometrial stromal sarcoma was supported by expression of CD10, Wilm tumor 1, estrogen receptor, and progesterone receptor and failure to express immunohistochemical markers characteristic of a range of differential diagnoses. In humans, this relatively uncommon neoplasm can arise from sites of endometriosis and often presents clinically as intestinal obstruction, similar to the presentation in this macaque.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Macaca mulatta Monkey Diseases Peritoneal Neoplasms Animals Diagnosis, Differential Endometriosis Endometriosis Endometriosis Female Immunohistochemistry Monkey Diseases Monkey Diseases Monkey Diseases Peritoneal Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms Tissue Adhesions

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

Cited by (1)

Source provenance

europepmc
last seen: 2026-06-12T06:13:51.797165+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:19:37.156494+00:00
License: CC0 · commercial use OK