Endometriosis in rhesus monkeys

B S Lindberg, Lindberg BS, S. Lindberg, Busch C, C Busch, Christer Busch
Upsala journal of medical sciences · 1984 · vol. 89(2) , pp. 129–134 · doi:10.3109/03009738409178472 · PMID:6464242 · W2018435651
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Endometriosis was found in five of six sacrificed Rhesus monkeys exhibiting symptoms like appetite loss and constipation, with the cause remaining unknown but likely due to retrograde menstruation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The paper reports that endometriosis was observed in 5 of 6 rhesus monkeys sacrificed for disease in a colony of 90, with clinical signs including loss of appetite, constipation, abdominal distension, and sometimes a palpable pelvic mass. At autopsy, the investigators found 300–500 ml of blood-stained abdominal fluid along with intestinal or pelvic endometriosis. The etiology was not determined, though the authors propose intraabdominal implantation of endometrial tissue via retrograde menstruation as the most probable explanation. The study is limited by the lack of information on why the lesion appears rarely in free-ranging colonies, including whether it relates to pregnancy frequency or to changes in menstruation frequency. This paper is centrally about endometriosis — it describes endometriosis occurrence, clinical presentation, and autopsy findings in rhesus monkeys and discusses a proposed mechanism.

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Abstract

Endometriosis was present in five out of six Rhesus monkeys who had to be sacrificed because of disease in a colony of 90. The monkeys lost appetite and became constipated. The abdomen was distended and often a pelvic mass could be palpated. At autopsy, 300-500 ml of blood-stained fluid was found in the abdomen together with intestinal or pelvic endometriosis. The ethiology of endometriosis in Rhesus monkeys is unknown. The most probable explanation is intraabdominal implantation of endometrial tissue through retrograde menstruation. The lesion is rare in animals in free ranging colonies. It is not known whether this is due to a higher frequency of pregnancies in animals with free access to matings or to its consequences, i.e. more infrequent menstruations.
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Endometriosis in Rhesus Monkeys Abstract Endometriosis was present in five out of six Rhesus monkeys who had to be sacrificed because of disease in a colony of 90. The monkeys lost appetite and became constipated. The abdomen was distended and often a pelvic mass could be palpated. At autopsy, 300–500 ml of blood-stained fluid was found in the abdomen together with intestinal or pelvic endometriosis. The ethiology of endometriosis in Rhesus monkeys is unknown. The most probable explanation is intraabdominal implantation of endometrial tissue through retrograde menstration. The lesion is rare in animals in free ranging colonies. It is not known whether this is due to a higher frequency of pregnancies in animals with free access to matings or to its consequences, i.e. more infrequent menstruations. Downloads Authors retain copyright of their work, with first publication rights granted to Upsala Medical Society. Read the full Copyright- and Licensing Statement.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Intestinal Neoplasms Monkey Diseases Ovarian Neoplasms Uterine Neoplasms Animals Animals Endometriosis Endometriosis Endometriosis Female Female Intestinal Neoplasms Intestinal Neoplasms Intestinal Neoplasms Intestines Intestines Intestines Macaca mulatta Macaca mulatta

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

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