Profile of Endometriosis in the Aging Female Rhesus Monkey

Christopher L. Coe, C L Coe, A M Lemieux, Andrine Lemieux, Sherry E. Rier, S E Rier, Hideo Uno, H Uno, Michele L. Zimbric, M L Zimbric
The journals of gerontology. Series A, Biological sciences and medical sciences · 1998 · vol. 53A(1) , pp. M3–M7 · doi:10.1093/gerona/53a.1.m3 · PMID:9467426 · W2140628363
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This study analyzed necropsy records to find that endometriosis incidence increases with age in rhesus monkeys, affecting up to 45% of those over 20 years old.

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Abstract

BACKGROUND: A retrospective analysis was conducted on necropsy records from a large rhesus monkey colony to evaluate the age-related prevalence of endometriosis. METHODS: A total of 314 records collected over a 15-year period were analyzed, yielding 66 monkeys with histologically verified endometriosis and 248 control subjects. RESULTS: The analyses demonstrated that the incidence of endometriosis increases progressively across the life span, ultimately impacting 21-45% of aged monkeys over 20 years of age. CONCLUSIONS: Because mild disease is often not diagnosed premortem, the endocrine and immune sequelae of endometriosis may be a potential confound in even nonreproductive research with aging primates. Prior research-related events influence the occurrence and severity of endometriosis in these long-lived animals, and specifically could have contributed to the high prevalence of endometriosis in this particular monkey colony.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Aging Aging Endometriosis Abdomen Abdomen Animals Body Weight Cause of Death Cohort Studies Confounding Factors, Epidemiologic Endometriosis Endometriosis Endometriosis Environmental Pollutants Environmental Pollutants Estradiol Estradiol Estradiol Female Incidence

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