Inhibition of IAP (inhibitor of apoptosis) proteins represses inflammatory status via nuclear factor‐kappa B pathway in murine endometriosis lesions

Fuminori Taniguchi, Takashi Uegaki, Kazuomi Nakamura, Khine Yin Mon, Takashi Harada, Tetsuya Ohbayashi, Tasuku Harada
American journal of reproductive immunology (New York, N.Y. : 1989) · 2017 · vol. 79(1) · doi:10.1111/aji.12780 · W2767890332
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The IAP antagonist BV6 reduced endometriotic lesion size and inflammatory gene expression in mice by inhibiting the NF-κB pathway.

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Abstract

Problem How is the role of inhibitor of apoptosis proteins ( IAP s) in the development of murine endometriosis lesions? Method of study BALB /c female mice (n = 36) were used for the murine endometriosis model. Endometriotic lesions were surgically induced in mice by transplanting mouse uterine tissue. After 4 weeks of IAP antagonist ( BV 6) treatment, the expression of inflammatory factors in the implants was evaluated using real‐time RT ‐ PCR . Inflammatory state, angiogenic activity, and nuclear factor‐kappa B ( NF ‐κB) activation were assessed by immunohistochemical staining. Results The number, size, and level of inflammatory cytokines (Vegf , Il‐6 , Ccl‐2, Lif ) gene expression in the murine endometriosis‐like lesions were reduced by BV 6 treatment. BV 6 repressed the intensity and rate of positive cells of CD 3, F4/80, and PECAM immunostaining; in addition, the expression of NF ‐κB p65 and phospho‐ NF ‐κB p65 was also attenuated. Conclusion Inhibitor of apoptosis proteins antagonist represses the inflammation status of murine endometriosis‐like lesions via NF ‐κB pathway. IAP s may be a novel therapeutic target for endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Inhibitor of Apoptosis Proteins NF-kappa B Animals Apoptosis Cell Proliferation Disease Models, Animal Down-Regulation Endometriosis Endometrium Endometrium Female Humans Inflammation Mediators Inflammation Mediators Inhibitor of Apoptosis Proteins Inhibitor of Apoptosis Proteins Mice Mice, Inbred BALB C

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