Inhibition of IAP (inhibitor of apoptosis) proteins represses inflammatory status via nuclear factor-kappa B pathway in murine endometriosis lesions

Fuminori Taniguchi, Uegaki T, Takashi Uegaki, Nakamura K, Kazuomi Nakamura, Khine Yin Mon, Mon KY, Takashi Harada, Tetsuya Ohbayashi, Ohbayashi T, Harada T, Tasuku Harada
American journal of reproductive immunology (New York, N.Y. : 1989) · 2017 · vol. 79(1) · doi:10.1111/aji.12780 · PMID:29105884 · W2767890332
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The IAP antagonist BV6 reduced endometriotic lesion size and inflammatory gene expression in mice by inhibiting the NF-κB pathway.

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Abstract

PROBLEM: How is the role of inhibitor of apoptosis proteins (IAPs) in the development of murine endometriosis lesions? METHOD OF STUDY: BALB/c female mice (n = 36) were used for the murine endometriosis model. Endometriotic lesions were surgically induced in mice by transplanting mouse uterine tissue. After 4 weeks of IAP antagonist (BV6) treatment, the expression of inflammatory factors in the implants was evaluated using real-time RT-PCR. Inflammatory state, angiogenic activity, and nuclear factor-kappa B (NF-κB) activation were assessed by immunohistochemical staining. RESULTS: The number, size, and level of inflammatory cytokines (Vegf, Il-6, Ccl-2, Lif) gene expression in the murine endometriosis-like lesions were reduced by BV6 treatment. BV6 repressed the intensity and rate of positive cells of CD3, F4/80, and PECAM immunostaining; in addition, the expression of NF-κB p65 and phospho-NF-κB p65 was also attenuated. CONCLUSION: Inhibitor of apoptosis proteins antagonist represses the inflammation status of murine endometriosis-like lesions viaNF-κB pathway. IAPs may be a novel therapeutic target for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Inhibitor of Apoptosis Proteins NF-kappa B Animals Animals Apoptosis Apoptosis Cell Proliferation Cell Proliferation Disease Models, Animal Disease Models, Animal Down-Regulation Down-Regulation Endometriosis Endometriosis Endometrium Endometrium Endometrium Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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