Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice

Yuan Lu, Jichan Nie, J. Nie, Xishi Liu, X. Liu, Yu Zheng, Sun-Wei Guo, Sun‐Wei Guo
Human Reproduction · 2010 · vol. 25(4) , pp. 1014–1025 · doi:10.1093/humrep/dep472 · PMID:20118114 · W2141380825
article OA: hybrid CC0 ⤵ 77 in-corpus citations
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Trichostatin A treatment in a mouse endometriosis model significantly reduced lesion size and pain sensitivity while altering markers of pain and neurotrophic factors.

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Abstract

BACKGROUND: The aim of this study was to evaluate the effect of trichostatin A (TSA) in a mouse model of endometriosis on serum tumour necrosis factor alpha (TNFalpha) levels, hotplate latency, lesion size and immunoreactivity to Trpv1, Pkcepsilon and Pgp9.5. METHODS: We used 30 adult female mice, and endometriosis was induced by auto-transplanting pieces of uterus (ENDO) or fat (SHAM) to peritoneum in lower parts of the abdominal and pelvic cavity. Two weeks later, the ENDO group was further divided into two groups randomly: one received TSA treatments and the other received injections of dimethyl sulfoxide, as did the SHAM mice. Four weeks later, all mice were sacrificed. Response latency in hotplate test and serum TNFalpha levels were measured before the surgery, and before and after the treatment, along with the average lesion size and the immunoreactivity to Trpv1, Pkcepsilon and Pgp9.5, in both eutopic and ectopic endometrium and vaginal tissue. RESULTS: We found that mice receiving TSA had a significantly reduced average lesion size as compared with untreated mice, as well as a significant improvement in response to a noxious thermal stimulus. They also had a significantly lower immunoreactivity to Trpv1 in eutopic endometrium, to Pkcepsilon in ectopic endometrium and to Pgp9.5 in vagina. CONCLUSIONS: Endometriosis causes increased central sensitivity to noxious stimuli. Treatment with TSA significantly reduces lesion growth and may relieve pain symptoms in women with endometriosis, indicating that histone deacetylase inhibitors may be a promising therapeutic agent.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Histone Deacetylase Inhibitors Hydroxamic Acids Animals Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Histone Deacetylase Inhibitors Humans Hydroxamic Acids Hyperalgesia Hyperalgesia Hyperalgesia Immunohistochemistry Mice Mice, Inbred C57BL Pain Threshold Pain Threshold

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