Additional file 1 of Activation of α7 nicotinic acetylcholine receptor retards the development of endometriosis

Hao, Meihua, Liu, Xishi, Guo, Sun-Wei
2022 · doi:10.6084/m9.figshare.20001068 · W6902200376
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study evaluated the number of endometriotic lesions in mice treated with PNU-282987, demonstrating that activation of the α7 nicotinic acetylcholine receptor retards endometriosis development.

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Abstract

Additional file 1: SupplementaryFigure S1. Positive andnegative controls for immunohistochemistry. For positive controls, human breastcancer tissues were used for E-cadherin, mouse liver tissues for α-SMA, humanadenomyotic tissue samples for desmin and SM-MHC, and mouse lung tissues for α7nAChR.For negative controls, mouse endometriotic lesions were used. Magnification: 400×;Scale bar: 50 μm. Supplementary Figure S2. Cysticappearance of endometriotic lesions in mouse experiment 1. Lesions seen fromExperiment 2 are similar. Supplementary Figure S3. The number ofendometriotic lesions per mouse was evaluated from the Control, PNU-282987 andMLA groups in mouse experiment 1. Symbols forstatistical significance levels: NS: p>0.05; *: p<0.05;**: p<0.01. SupplementaryFigure S4. H&E staining from endometriotic lesions. Magnification = 200×, scale bar=100 μm. Supplementary Figure S5. The number of endometrioticlesions per mouse was evaluated from the Control and PNU-282987 groups in mouse experiment 2. NS: p>0.05.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (54)

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