The anti-inflammatory impact of omega-3 polyunsaturated Fatty acids during the establishment of endometriosis-like lesions

Jill Attaman, Jill A Attaman, Attaman JA, Stanic AK, Aleksandar K. Stanic, Kim M, Minji Kim, Lynch MP, Maureen P. Lynch, Bo R. Rueda, Rueda BR, Styer AK, Aaron K. Styer
American journal of reproductive immunology (New York, N.Y. : 1989) · 2014 · vol. 72(4) , pp. 392–402 · doi:10.1111/aji.12276 · PMID:24898804 · W2043358672
Lab / animal OA: closed CC0 ⤵ 31 in-corpus citations
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This study utilized uterine transplants in mice with varying omega-3 fatty acid levels to demonstrate that systemic omega-3s reduce inflammatory cytokines, Cox-2, and proliferation markers in early endometriosis-like lesions.

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Abstract

PROBLEM: The anti-inflammatory impact of three polyunsaturated fatty acids (3-PUFA) in endometriosis is incompletely understood. The effect of 3-PUFA on endometriosis-like lesions is evaluated as a potential anti-inflammatory treatment target. METHOD OF STUDY: Wild Type (WT) and transgenic Fat-1 mice (high levels of endogenous 3-PUFA) were utilized in a uterine tissue transplant endometriosis model. Experimental donor×host pairs included: WT×WT (WW), WT×Fat-1 (WF), and Fat-1×Fat-1 (FF). Cytokine content (IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, IL-17A, IFN-γ, TNF-γ, MCP-1 and RANTES) and immunocellular composition in lesions was determined. RESULTS: Intralesion IL-6 in WF hosts was 99-fold lower than WW hosts (P=0.03). Compared to WW host lesions, Cox-2 levels were decreased in WF [1.5-fold (P=0.02)] and FF [1.2-fold (P=0.01)] host lesions, respectively, and intralesion VEGF expression was increased [1.8-fold; P=0.02 (WF) and 1.5-fold; P=0.01 (FF)]. Lesions in FF hosts demonstrated reduced phosphohistone 3 expression (70%; P=0.03) compared to WW control hosts. CONCLUSIONS: Systemic host 3-PUFA levels influence immune, angiogenic, and proliferative factors implicated in the early establishment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents Cytokines Endometriosis Endometriosis Fatty Acids, Omega-3 Animals Animals Anti-Inflammatory Agents Anti-Inflammatory Agents B-Lymphocytes B-Lymphocytes B-Lymphocytes Cyclooxygenase 2 Cyclooxygenase 2 Cyclooxygenase 2 Cytokines Cytokines Cytokines Diet Diet

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

Cited by (31)

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