Substance P in peritoneal fluid
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This study investigated the presence and significance of substance P in peritoneal fluid.
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Abstract
Substance P is a neuropeptide that has been identified in the ovary, fallopian tube, uterus, and vagina and in the hypothalamic-pituitary axis in both an animal model and human ovaries. We sought to determine if substance P is present in peritoneal fluid and, if so, whether it correlated with the cause of infertility. Its presence was determined by radioimmunoassay in the peritoneal fluid of 66 patients undergoing diagnostic laparoscopy for clinical indications related to infertility. Total volume of peritoneal fluid and cycle day were recorded; patients were evaluated in groups according to diagnosis: endometriosis (n = 24), pelvic adhesions (n = 18), and normal controls (n = 24). The level of substance P (mean +/- SEM) was 122 +/- 19 pg/ml for endometriosis and 130 +/- 19 pg/ml for pelvic adhesions. These values were not significantly different from the normal controls (130 +/- 25 pg/ml). There was no significant difference in levels between follicular and luteal phase of the menstrual cycle. We conclude that substance P is present normally in peritoneal fluid and that its levels are not affected by pelvic endometriosis or adhesions.
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Cited by (13)
- Study on epidemiology of endometriosis in North East India 2023
- Assessing Pain Behavioral Responses and Neurotrophic Factors in the Dorsal Root Ganglion, Serum and Peritoneal Fluid in Rat Models of Endometriosis 2021
- Zinc(II) niflumato complex effects on MMP activity and gene expression in human endometrial cell lines 2021
- Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis 2021
- Invasion and nerve fibers damage in endometriosis 2020
- A study of prevalence, severity, stages, conception rate and associated problems in patients with endometriosis 2019
- Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics 2016
- Inflammation and nerve fiber interaction in endometriotic pain 2014
- Induction of the Neurokinin 1 Receptor by TNFα in Endometriotic Tissue Provides the Potential for Neurogenic Control Over Endometriotic Lesion Growth 2013
- Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity 2012
- Urethral Diverticulum with Endometriosis 2008
- Neuroendocrine–immune disequilibrium and endometriosis: an interdisciplinary approach 2007
- Effect of peritoneal fluid from patients with mild and severe endometriosis on endometrial stromal cell proliferation 1997
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- europepmc
- last seen: 2026-07-31T06:09:14.520117+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:11:54.876058+00:00
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