Is it possible to diagnose endometriosis at the level of endometrium?

Maria Szubert, Magdalena Ziętara, Jacek Suzin
In: Current Gynecologic Oncology · 2016 · vol. 14(1) , pp. 30–38 · doi:10.15557/cgo.2016.0004 · W2516629179
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Endometrial expression of cytokines, angiogenic, and hormonal factors differs between women with and without endometriosis, offering potential targets for non-invasive diagnosis.

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The paper considers whether endometriosis could be diagnosed using endometrial tissue, given that women with endometriosis reportedly have different expression of cytokines, angiogenic, and hormonal factors in the endometrium compared with healthy women. It reviews the current diagnostic gap, noting that no endometriosis-specific marker has been identified and that laparoscopy remains the gold standard, particularly for peritoneal disease not visible on ultrasound. The authors highlight selected endometrial factors—including interleukin 8, vascular endothelial growth factor, platelet-derived growth factor, and nerve growth factor—as potential diagnostic targets, while emphasizing the lack of a validated marker combination that achieves high sensitivity and specificity. This paper is centrally about endometriosis — it focuses on evaluating endometrial cytokine and growth-factor expression as potential non-invasive diagnostic targets for endometriosis.

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Abstract

The endometrium of women with endometriosis has a different expression of cytokines, angiogenic and hormonal factors compared to healthy women. Endometriosis is a disease occurring mostly in women at a reproductive age with a frequency of 7–10%. Despite many studies and hypotheses on the pathogenesis of the disease, marker specific to endometriosis has not yet been detected. Thus, laparoscopy remains the gold standard in the diagnosis, particularly in the case of peritoneal form that cannot be visualized by means of an ultrasound test. Other forms of endometriosis – ovarian (chocolate cysts) and deep infiltrating – can be identified in an ultrasound test. Scientists are currently searching for markers that in a specific combination would ensure maximum sensitivity and specificity of the non-invasive detection of endometriosis, even at early stages. The article presents selected factors, such as interleukin 8, vascular endothelial growth factor, platelet-derived growth factor, nerve growth factor, detected in the endometrium, which can be a potential diagnostic target. Diagnoses made at the level of endometrium would facilitate the identification of endometriosis and would significantly reduce costs associated with the necessity to conduct laparoscopy.
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Is it possible to diagnose endometriosis at the level of endometrium? Maria Szubert1, Magdalena Ziętara2, Jacek Suzin1 The endometrium of women with endometriosis has a different expression of cytokines, angiogenic and hormonal factors compared to healthy women. Endometriosis is a disease occurring mostly in women at a reproductive age with a frequency of 7–10%. Despite many studies and hypotheses on the pathogenesis of the disease, marker specific to endometriosis has not yet been detected. Thus, laparoscopy remains the gold standard in the diagnosis, particularly in the case of peritoneal form that cannot be visualized by means of an ultrasound test. Other forms of endometriosis – ovarian (chocolate cysts) and deep infiltrating – can be identified in an ultrasound test. Scientists are currently searching for markers that in a specific combination would ensure maximum sensitivity and specificity of the non-invasive detection of endometriosis, even at early stages. The article presents selected factors, such as interleukin 8, vascular endothelial growth factor, platelet-derived growth factor, nerve growth factor, detected in the endometrium, which can be a potential diagnostic target. Diagnoses made at the level of endometrium would facilitate the identification of endometriosis and would significantly reduce costs associated with the necessity to conduct laparoscopy.

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endometriosis

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