Profiling of selected angiogenesis-related genes in proliferative eutopic endometrium of women with endometriosis

P Laudanski, Piotr Laudański, R Charkiewicz, Radosław Charkiewicz, Mariusz Kuźmicki, M Kuzmicki, Jacek Szamatowicz, J Szamatowicz, Świątecka J, J Swiatecka, J Świątecka, B Mroczko, Barbara Mroczko, Niklinski J, J. Niklinski, Jacek Nikliński
European journal of obstetrics, gynecology, and reproductive biology · 2013 · vol. 172 , pp. 85–92 · doi:10.1016/j.ejogrb.2013.10.007 · PMID:24188612 · W1987693231
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This study profiled selected angiogenesis-related genes in proliferative eutopic endometrium from women with endometriosis, comparing them to controls.

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Abstract

ObjectiveTo compare the expression level of the most relevant angiogenesis-related genes in the eutopic endometrium of women with and without endometriosis.Study design32 regularly menstruating patients (18 with endometriosis and 14 controls) underwent surgery in the proliferative phase of the cycle. Eutopic endometrium was collected by the use of aspirating biopsy prior to laparoscopy. Only patients with advanced (stage III and IV) histopathologically confirmed ovarian endometriosis were studied. Real-time PCR gene arrays were applied to examine the expression of 84 human angiogenesis-connected genes. Western-blot and enzyme-linked immunosorbent assays (ELISA) were used to confirm the expression of selected proteins.ResultsWe found significantly higher levels of AKT1 (p=0.003), TYMP (p=0.02), JAG1 (p=0.007), LAMA5 (p=0.005) and TIMP-1 (p=0.03) in eutopic endometrium of patients with endometriosis as compared with controls. By the use of Western blot we found clearly positive expression of AKT1 whereas ELISA assays confirmed expression of AKT1, TYMP, JAG1, LAMA5 and TIMP1.ConclusionChanges in the expression of selected genes might lead to or be a consequence of an early defect in the physiological activity of proliferative endometrium ultimately resulting in its overgrowth outside the uterine cavity.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Follicular Phase Neovascularization, Pathologic Neovascularization, Physiologic Ovarian Diseases RNA, Messenger Adult Calcium-Binding Proteins Calcium-Binding Proteins Calcium-Binding Proteins Case-Control Studies Endometriosis Endometriosis Endometrium Endometrium Enzyme-Linked Immunosorbent Assay Female Follicular Phase Follicular Phase

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