DNA microarray analysis in endometriosis for development of more effective targeted therapies

Sachiko Matsuzaki
Frontiers in bioscience (Elite edition) · 2011 · vol. E3(3) , pp. 1139–1153 · doi:10.2741/e317 · PMID:21622120 · W2317363559
review OA: bronze CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review analyzes DNA microarray findings over a decade to enhance understanding of endometriosis pathophysiology and inform targeted therapy development.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper is a literature review focused on how DNA microarray technologies have been used in endometriosis research to generate new findings about pathophysiology and disease etiology. It surveys results from gene expression profiling, microarray-based comparative genomic hybridization (array CGH), single nucleotide polymorphism (SNP) arrays, and ChIP-on-chip approaches, emphasizing findings from roughly a decade of experience and their context in clinical studies. A key limitation is that, as a review, it synthesizes prior work rather than presenting new experimental data, so it does not provide a single unified experimental estimate of effect. This paper is centrally about endometriosis — it specifically reviews endometriosis pathophysiology findings derived from DNA microarray technologies.

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Abstract

Microarray technology has become a widely used tool for analyzing the expression of tens of thousands of genes simultaneously on high-density microarrays in a single experiment, together with the availability of the complete nucleotide sequence of the human genome. DNA microarray technologies are powerful tools in the laboratory setting for scientific research, hypothesis generation, and the production of leads for subsequent validation through more sophisticated technologies. Since 2002, and particularly in the past few years, the utility of various DNA microarray technologies in endometriosis has rapidly and tremendously evolved; DNA microarray studies provide extremely important information that enable a better understanding of pathophysiology and disease etiology. This is a review of the literature focused on new findings of endometriosis pathophysiology obtained using various microarray technologies: gene expression profiling, microarray-based comparative genomic hybridization (CGH) (array CGH) single nucleotide polymorphism (SNP) arrays, the combination of chromatin immunoprecipitation (ChIP) with hybridization of microarrays (ChIP-on-chip). The present review discusses the results of a decade of DNA microarray technology experience, with emphasis on the pathophysiology of endometriosis in the context of clinical studies.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Oligonucleotide Array Sequence Analysis Chromatin Immunoprecipitation Comparative Genomic Hybridization Endometriosis Female Gene Expression Humans Polymorphism, Single Nucleotide

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (96)

Cited by (4)

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