Aberrant methylation of the IL‐12B promotor region contributes to the risk of developing ovarian endometriosis

Wei Zhao, Zhao W, Shan Kang, Zhao J, Jian Zhao, Wang L, Lixian Wang, Cao S, Shiru Cao, Yan Li
Molecular reproduction and development · 2019 · vol. 86(6) , pp. 632–638 · doi:10.1002/mrd.23139 · PMID:30865360 · W2921194554
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Aberrant hypomethylation of the IL-12B promoter region in eutopic and ectopic endometrium is associated with increased IL-12B mRNA expression and may contribute to ovarian endometriosis development.

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Abstract

Studies have shown that aberrant expression of IL-12p40, which is encoded by the interleukin-12B (IL-12B) gene, may be involved in the development of endometriosis. In this study, we investigated the role of aberrant methylation of the IL-12B promoter region and its associated expression in the development of ovarian endometriosis. By using pyrosequencing, we analyzed the methylation level of the IL-12B promoter region in eutopic and ectopic endometrium of patients with ovarian endometriosis and normal endometrium of control women. The expression of IL-12B mRNA was detected by quantitative real-time PCR. The results showed that the methylation level of the IL-12B promoter region in ectopic and eutopic endometrium of patients with ovarian endometriosis was significantly lower than that in endometrium of women without endometriosis ( p < 0.001 and p = 0.041, respectively). In contrast, mRNA levels were significantly increased in ectopic and eutopic endometrium of patients with ovarian endometriosis compared to those in endometrium of women without endometriosis ( p < 0.001 and p = 0.042, respectively). Correlation analysis showed that the methylation level of the IL-12B promoter region was negatively correlated with mRNA levels of IL-12B ( p < 0.001). Our data suggested that aberrant methylation of the IL-12B promoter region may be responsible for aberrant IL-12B mRNA expression in endometrium tissue of women, which may be associated with the development of ovarian endometriosis in northern Chinese women.

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Condition tags

endometriosis

MeSH descriptors

DNA Methylation Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Gene Expression Regulation Interleukin-12 Subunit p40 Interleukin-12 Subunit p40 Interleukin-12 Subunit p40 Promoter Regions, Genetic Adult Case-Control Studies Female Humans Middle Aged

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