Silencing Cofilin‐1 blocks PDGF‐induced proliferation in eutopic endometrium of endometriosis patients

Wang DB, Dan-bo Wang, Dan‐Bo Wang, Xu YL, Yan-Li Xu, Yanli Xü, Chen P, Peng Chen, Chen YH, Ying-Han Chen, Yinghan Chen, Yan Li, Li Y
Cell biology international · 2013 · vol. 37(8) , pp. 799–804 · doi:10.1002/cbin.10093 · PMID:23505076 · W1585761632
article OA: closed CC0 ⤵ 3 in-corpus citations
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Platelet-derived growth factor (PDGF) stimulates eutopic endometrium stromal cell (ESC) proliferation by increasing Cofilin-1 (CFL1) expression, and silencing CFL1 blocks this proliferative effect.

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Abstract

Platelet-derived growth factor (PDGF) is well known to induce proliferation in variety of cells. The aim of this study was to investigate whether there is a correlation between the expression of Cofilin-1 (CFL1) and the proliferation of eutopic endometrium stromal cells (ESC) in response to PDGF stimulation. Results show that PDGF induced the expression of CFL1 in ESC and promoted proliferation of ESC significantly in a time- or dose-dependent manner. After silencing CFL1, the effect of PDGF on promoting ESC proliferation was significantly decreased. These data demonstrate that PDGF can induce CFL1 expression in ESC. Silencing CFL1 blocks PDGF-induced proliferation in ESC.

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Condition tags

endometriosis

MeSH descriptors

Cell Proliferation Cofilin 1 Endometriosis Endometrium Platelet-Derived Growth Factor Adult Cells, Cultured Cofilin 1 Cofilin 1 Endometriosis Endometrium Endometrium Female Gene Expression Gene Knockdown Techniques Humans Middle Aged Platelet-Derived Growth Factor RNA, Small Interfering RNA, Small Interfering

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References (24)

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