Silencing Cofilin-1 blocks PDGF-induced proliferation in eutopic endometrium of endometriosis patients

Wang DB, Dan-bo Wang, Dan‐Bo Wang, Xu YL, Yan-Li Xu, Yanli Xü, Chen P, Peng Chen, Chen YH, Ying-Han Chen, Yinghan Chen, Yan Li, Li Y
Cell biology international · 2013 · vol. 37(8) , pp. 799–804 · doi:10.1002/cbin.10093 · PMID:23505076 · W1585761632
Lab / animal OA: closed CC0 ⤵ 3 in-corpus citations
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Platelet-derived growth factor (PDGF) stimulates eutopic endometrium stromal cell (ESC) proliferation by increasing Cofilin-1 (CFL1) expression, and silencing CFL1 blocks this proliferative effect.

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Abstract

Platelet-derived growth factor (PDGF) is well known to induce proliferation in variety of cells. The aim of this study was to investigate whether there is a correlation between the expression of Cofilin-1 (CFL1) and the proliferation of eutopic endometrium stromal cells (ESC) in response to PDGF stimulation. Results show that PDGF induced the expression of CFL1 in ESC and promoted proliferation of ESC significantly in a time- or dose-dependent manner. After silencing CFL1, the effect of PDGF on promoting ESC proliferation was significantly decreased. These data demonstrate that PDGF can induce CFL1 expression in ESC. Silencing CFL1 blocks PDGF-induced proliferation in ESC.

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Condition tags

endometriosis

MeSH descriptors

Cell Proliferation Cell Proliferation Cofilin 1 Endometriosis Endometrium Platelet-Derived Growth Factor Adult Adult Cells, Cultured Cells, Cultured Cofilin 1 Cofilin 1 Cofilin 1 Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

Cited by (3)

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