In-vitro adhesion of endometrium to autologous peritoneal membranes: effect of the cycle phase and the stage of endometriosis
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This study found that endometrium adheres to autologous peritoneum in vitro across all menstrual cycle phases and regardless of endometriosis presence or stage, with observed mesothelial disruption and epithelialization.
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Abstract
BACKGROUND: Endometrium can adhere to autologous peritoneum. This study was undertaken to determine the effect of the menstrual cycle phase and the presence and stage of endometriosis on in-vitro adhesion of endometrium onto autologous peritoneum. METHODS: This was performed in an academic medical research centre. Sixty-seven subfertile women with a visually normal pelvis (n = 18) and with biopsy-proven endometriosis (n = 49) were included. Endometrial and peritoneal biopsies were obtained at laparoscopy during menstrual, follicular and luteal phase. Endometrium was cultured in vitro with autologous peritoneum, followed by fixation, paraffin embedding, serial sectioning, hematoxylin-eosin and immunohistochemical staining. Endometrial-peritoneal adhesion was evaluated using light microscopy. RESULTS: Endometrial-peritoneal adhesion was observed in approximately 80% of the adhesion assays and was not affected by the phase of the cycle, or by the presence and stage of endometriosis. The continuity of the mesothelial layer was disrupted at the attachment sites. Epithelialization was observed along the edges to integrate the endometrial implant. After adhesion, histological changes were observed within and below the implant. CONCLUSIONS: Endometrium obtained during menstrual, follicular or luteal phase appears to have a similar potential to implant in vitro on autologous peritoneum, and this adhesion process is not affected by the stage of endometriosis.
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- Short-term culture of peritoneum explants confirms attachment of endometrium to intact peritoneal mesothelium via openalex
- Whole Endometrial Fragments Form Characteristics of In Vivo Endometriosis in a Mesothelial Cell Co-Culture System: An In Vitro Model for the Study of the Histogenesis of Endometriosis via openalex
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Cited by (18)
- Mouse model for endometriosis is characterized by proliferation and inflammation but not epithelial-to-mesenchymal transition and fibrosis 2020
- Menstrual endometrial supernatant may induce stromal endometriosis in baboons 2014
- Models of Endometriosis:<i>In vitro</i>and<i>In vivo</i>Models 2011
- Models of Endometriosis: Animal Models II – Non‐Human Primates 2011
- Deeply Infiltrative Endometriosis: Clinical Outcome after Surgery in Adults and Pathways to Potential Prevention in Adolescents 2011
- Tumor Necrosis Factor-α and Interleukin-1β Treatment of Endometrial Stromal Cells Does not Promote Their Adhesion to Peritoneal Mesothelial Cells in an in Vitro Model of Early-Stage Endometriosis 2011
- Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities 2011
- Semi-invasive Diagnosis of Endometriosis Doctoral Thesis 2010
- Baboon Model for Endometriosis 2009
- The non-human primate model of endometriosis: research and implications for fecundity 2009
- REVIEW ARTICLE: Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids 2008
- Paracrine regulation of endometriotic tissue 2007
- Future of Endometriosis Research 2007
- A baboon model for endometriosis: implications for fertility 2006
- Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis 2006
- Tumour necrosis factor-α, interleukin-6 and interleukin-8 do not promote adhesion of human endometrial epithelial cells to mesothelial cells in a quantitative in vitro model* 2005
- Macrophage stimulating protein/RON system: A potential novel target for the prevention and treatment in endometriosis 2004
- Potential involvement of the immune system in the development of endometriosis 2003
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- europepmc
- last seen: 2026-07-26T06:08:39.051465+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:13:01.552487+00:00
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