ORIGINAL ARTICLE: Leptin on Peritoneal Macrophages of Patients with Endometriosis

Meng-Hsing Wu, Meng‐Hsing Wu, Mei-Feng Huang, Mei‐Feng Huang, Fong-Ming Chang, Fong‐Ming Chang, Shaw-Jenq Tsai, Shaw‐Jenq Tsai
American journal of reproductive immunology (New York, N.Y. : 1989) · 2009 · vol. 63(3) , pp. 214–221 · doi:10.1111/j.1600-0897.2009.00779.x · PMID:20047585 · W1799831569
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that elevated leptin in peritoneal fluid from endometriosis patients induces COX-2 expression and prostaglandin F(2alpha) production in peritoneal macrophages.

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Abstract

PROBLEM: The expression of cyclooxygenase (COX)-2 is considered as a marker of macrophage activation and has been implicated in the development of endometriosis. Leptin is an immunomodulator, which may also affect the development of endometriosis. However, how leptin contributes to these pathological processes has not been completely understood. The aim of this study was to investigate the effects of leptin on peritoneal macrophages and its relationship with endometriosis. METHODS OF STUDY: Peritoneal fluid from 60 women of reproductive age was obtained while they underwent laparoscopy. Forty patients had endometriosis and 20 patients did not have endometriosis. The concentration of leptin in the peritoneal fluid and prostaglandin F(2alpha) levels was measured by ELISA, and the other protein expression using Western blot when peritoneal macrophages were stimulated with leptin. RESULTS: Concentration of leptin in peritoneal fluid was increased in patients with endometriosis compared with disease-free normal control. Functional leptin receptor was present in peritoneal macrophages. Treatment of peritoneal macrophages with leptin induced COX-2 expression. Production of prostaglandin F(2alpha) by peritoneal macrophages was increased after leptin stimulation in women with endometriosis. CONCLUSION: Elevated concentration of leptin in peritoneal fluid may contribute to the pathological process of endometriosis through activation of peritoneal macrophages.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Leptin Macrophages, Peritoneal Adult Ascitic Fluid Ascitic Fluid Cyclooxygenase 2 Cyclooxygenase 2 Dinoprost Dinoprost Endometriosis Female Humans Interleukin-1 Interleukin-1 Leptin Macrophage-Activating Factors Macrophage-Activating Factors Macrophages, Peritoneal Receptors, Interleukin-1

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (17)

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