The expression of vascular endothelial growth factor is affected by hypoxia inducible factor-1α in peritoneum of endometriosis mice treated with genistein

Sylvi Wafda Nur Amellia, Yuyun Yueniwati, Sutrisno Sutrisno
In: Middle East Fertility Society Journal · 2016 · vol. 21(3) , pp. 180–183 · doi:10.1016/j.mefs.2015.12.005 · W2272686974
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Genistein treatment significantly attenuated increased expressions of VEGF-A and HIF-1α in the peritoneum of a mouse model of endometriosis.

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Abstract

This study aimed to investigate whether the genistein is able to decrease the expressions of vascular endothelial growth factor-A (VEGF-A) and hypoxia inducible factor-1α (HIF-1α) in mouse model of endometriosis. Forty female mice (Mus musculus) were divided into eight groups (n = 5 each), including the control (untreated) group, endometriosis group, and endometriosis groups treated with various doses of genistein (50; 100; 200; 300; 400; and 500 mg/day). VEGF-A and HIF-1α analyses were performed by immunohistochemistry. We found significant increases in the VEGF-A and HIF-α expressions in endometriosis group compared to the control group. The increased expressions of VEGF-A and HIF-1α were significantly (p < 0.05) attenuated by the administration of all doses of genistein. In conclusion, in mouse model of endometriosis, genistein potentially inhibits the increase in angiogenesis in peritoneal tissue. Therefore, this result may provide a novel anti-angiogenic treatment strategy for the therapy of endometriosis.

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endometriosis

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