Decreased peritoneal concentrations of interleukin-15 in women with advanced stage endometriosis

Jun Lin, Lin J, Zhang X, Xinmei Zhang, Lin Deng, Deng Lin, Lin D, Qingxian Fang, Fang Q, Yuli Qian, Qian Y
European journal of obstetrics, gynecology, and reproductive biology · 2006 · vol. 129(2) , pp. 169–173 · doi:10.1016/j.ejogrb.2006.01.005 · PMID:16876309 · W2082545332
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This study investigated peritoneal fluid cytokine levels and found significantly lower concentrations of interleukin-15 in women diagnosed with advanced stage endometriosis compared to controls.

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Abstract

ObjectiveTo assess the concentrations of interleukin-15 (IL-15) in peritoneal fluid from women with endometriosis and fertile disease-free controls.Study designPeritoneal fluid samples were obtained from 50 women with endometriosis and 29 fertile women having tubal ligation. Concentrations of IL-15 were measured.ResultsThe mean (S.D.s) concentration of IL-15 in peritoneal fluid was 11.17 pg/mL (3.89) for women with endometriosis, and 12.59 pg/mL (4.11) for fertile disease-free controls. The difference of peritoneal IL-15 concentrations between endometriosis and control women was not statistically significant. However, peritoneal IL-15 concentrations were significantly lower in women with moderate/severe endometriosis when compared with those in women with minimal/mild endometriosis, and in controls (P<0.05). In addition, peritoneal IL-15 concentrations did not correlate with the phase of menstrual cycle in endometriosis or control women.ConclusionsOur results suggest that the decreased peritoneal IL-15 concentrations in women with moderate/severe endometriosis imply a role of IL-15 in the pathogenesis of advanced endometriosis as compared to those with minimal/mild endometriosis and fertile disease-free controls.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-15 Adult Ascitic Fluid Ascitic Fluid Case-Control Studies Endometriosis Endometriosis Female Humans Interleukin-15 Interleukin-15 Interleukin-15 Laparoscopy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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