Changes in immunologic variables (TNF-a, sCD8 and sCD4) during danazol treatment in patients with endometriosis
Non-randomised trial
OA: closed
CC0
⤵ 20 in-corpus citations
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Danazol treatment significantly reduced elevated TNF-a and sCD8 levels in women with endometriosis compared to pre-treatment and control groups.
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Abstract
DESIGN: The levels of TNF-a, sCD8, and sCD4 were measured in serum samples taken from 20 women. Blood samples for TNF-a, sCD8 and sCD4 levels were taken from 10 endometriotic women before treatment, during the last 15 days of a 6-month administration of danazol and 3 months after treatment. Blood samples were taken only once from 10 women without endometriosis (control group).
RESULTS: TNF-a levels were higher in women with endometriosis before treatment compared to controls (P < .05). Administration of the drug significantly reduced the levels of TNF-a (P < .01) and sCD8 (P < .001).
CONCLUSION: This study indicates that danazol significantly reduces endometriosis-associated autoimmune abnormalities.
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Cited by (20)
- Genistein modulates the estrogen receptor and suppresses angiogenesis and inflammation in the murine model of peritoneal endometriosis 2017
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Identifying biomarkers for non-invasive diagnosis of endometriosis 2016
- Effect of genistein on proinflammatory cytokines and estrogen receptor–β in mice model of endometriosis 2015
- Investigation of serum proteome alterations in human endometriosis 2014
- The effects of genistein as antiinflammatory and antiangiogenesis in primary endometriosis cell culture 2014
- New horizons in the non-invasive diagnosis of endometriosis 2013
- Immune interactions in endometriosis 2011
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Decreased peritoneal concentrations of interleukin-15 in women with advanced stage endometriosis 2006
- Serum levels of VEGF and TNF-alpha and their association with C-reactive protein in patients with endometriosis 2005
- ecreased levels of interleukin-18 in eritoneal fluid but not in serum of atients with endometriosis 2004
- Decreased levels of interleukin-18 in peritoneal fluid but not in serum of patients with endometriosis 2004
- Serum concentrations of growth factors in women with and without endometriosis: the action of anti-endometriosis medicines 2003
- Endometriosis is sustained by tumour necrosis factor-alpha 2002
- Soluble ICAM-1 levels in the serum of endometriotic patients appear to be independent of medical treatment 2001
- The anti-inflammatory action of danazol and leuprorelin acetate depot on endometriosis is CRH independent 2001
- The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with endometriosis after treatment with danazol and leuprorelin acetate depot 2001
- Three-year follow-up of [CA-125, CA 19-9, CA 15-3, SIL-2R, IL-6, IL-la, TNF-a, sCD8 and sCD4] levels in a woman with severe endometriosis 2000
- A randomized comparison of danazol and leuprolide acetate suppression of serum-soluble CD23 levels in endometriosis 2000
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