Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis

Marek Gogacz, Izabela Winkler, Agnieszka Bojarska-Junak, Agnieszka Bojarska−Junak, Jacek Tabarkiewicz, Andrzej Semczuk, Tomasz Rechberger, Aneta Adamiak
Journal of Reproductive Immunology · 2016 · vol. 117 , pp. 39–44 · doi:10.1016/j.jri.2016.04.289 · PMID:27371900 · W2399182235
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This study found that a higher proportion of Th17 cells in peritoneal fluid correlates with increased endometriosis severity.

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Abstract

AimTh17 cells are a newly discovered T helper lymphocyte subpopulation, producing interleukin IL-17. Th17 cells are present in blood and peritoneal fluid (PF) at different stages of endometriosis. We aim to establish their potential importance in the pathogenesis and clinical features of the disease.MethodsThe percentage of Th17 cells among T helper lymphocytes was determined in the PF and peripheral blood (PB) of patients with endometriosis and in the control group by flow cytometry using monoclonal antibodies: anti-CD-4-FITC, anti-CD-3-PE/Cy5, and anti-IL-17A-PE.ResultsTh17 percentage is increased in PF in comparison with PB in both endometriotic patients and in the control group. In severe endometriosis, the percentage of Th17 cells in PF was higher than with early (I/II stage) endometriosis. A positive correlation between the percentage of Th17 cells in PF and the white blood cell count in PB was found in patients with endometriosis.ConclusionTargeting the activity of PF Th17 cells may have an influence on the proliferation of ectopic tissue and clinical manifestations of the disease.

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Condition tags

endometriosis

MeSH descriptors

Blood Cells Endometriosis Peritoneum Th17 Cells Adult Blood Cells Cell Proliferation Cell Separation Disease Progression Endometriosis Female Flow Cytometry Humans Lymphocyte Count Peritoneum Th17 Cells

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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