Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis

Menghe Liu, Ru Peng, Chunfang Tian, Jianping Shi, Jiannan Ma, Ruiwen Shi, Xiao Qi, Rongwei Zhao, Haibin Guan
Frontiers in cellular and infection microbiology · 2024 · vol. 14 , pp. 1373004 · doi:10.3389/fcimb.2024.1373004 · PMID:38938880 · PMC11208329
review OA: gold CC-BY-4.0
📄 Open PDF View on PubMed View at publisher

Abstract

In recent years, a growing body of research has confirmed that the gut microbiota plays a major role in the maintenance of human health and disease. A gut microbiota imbalance can lead to the development of many diseases, such as pregnancy complications, adverse pregnancy outcomes, polycystic ovary syndrome, endometriosis, and cancer. Short-chain fatty acids are metabolites of specific intestinal bacteria and are crucial for maintaining intestinal homeostasis and regulating metabolism and immunity. Endometriosis is the result of cell proliferation, escape from immune surveillance, and invasive metastasis. There is a strong correlation between the anti-proliferative and anti-inflammatory effects of short-chain fatty acids produced by gut microbes and the development of endometriosis. Given that the mechanism of action of gut microbiota and Short-chain fatty acids in endometriosis remain unclear, this paper aims to provide a comprehensive review of the complex interactions between intestinal flora, short-chain fatty acids and endometriosis. In addition, we explored potential microbial-based treatment strategies for endometriosis, providing new insights into the future development of diagnostic tests and prevention and treatment methods for endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Fatty Acids, Volatile Fatty Acids, Volatile Fatty Acids, Volatile Fatty Acids, Volatile Fatty Acids, Volatile Fatty Acids, Volatile Fatty Acids, Volatile Fatty Acids, Volatile Gastrointestinal Microbiome Gastrointestinal Microbiome Gastrointestinal Microbiome

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

SciLite annotations

organisms 61
microbiota human microbiota bacteria stick insect bacteria stick insect human microbiota human bacteria stick insect mycota mycoplasmatales bacterium metabacteria viruses human bacteria stick insect low g+c gram-positive bacteria bacteroidia purple photosynthetic bacteria and relatives actinomycetota bacteria stick insect microbiota old world monkeys old world monkeys paralactobacillus photosynthesizing gram-positive bacteria mus sp. capsularis bacteria stick insect microbiota microbiota microbiota lactic acid bacterium zjgs0603 mus sp. zitter rats bacteria stick insect bacteria stick insect microbiota feces metagenome unknown eubacterium mus sp. mus sp. unknown eubacterium bacteria stick insect microbiota microbiota mus sp. bacteria stick insect bacteria stick insect bacteria stick insect mosquito plant low g+c gram-positive bacteria rodents capsularis transgenic mice mus sp. bacteria stick insect microbiota microbiota microbiota microbiota +1 more
chemicals 39
short-chain fatty acid long-chain carboxylate polyunsaturated fatty acid n-[(2r,3r,4r,5s,6r)-2-[[(2r,3r,4r,5r,6s)-5-acetamido-6-[(2r,3r,4s,5s,6r)-2-[(2r,3r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,3s,4r,5r,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3-hydroxy-4-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide polyunsaturated fatty acid short-chain fatty acid polyunsaturated fatty acid estrogen short-chain fatty acid butyrate propionate acetate n-acetylmethioninate n-acetylmethioninate lipopolysaccharide monounsaturated fatty acid short-chain fatty acid arabinoxylan butyrate acetate propionate butyric acid butyrate butyrate bile acids bile acid chenodeoxycholic acid acetate butyrate short-chain fatty acid omega-3 fatty acid omega-3 fatty acid omega-3 fatty acid linolenic acid prostaglandin e2 nitrite trans-fatty acid estrogen bile acids

Source provenance

europepmc
last seen: 2026-06-25T06:14:32.897245+00:00
pubmed
last seen: 2026-06-11T06:17:30.685761+00:00
scilite
last seen: 2026-05-18T04:26:01.642840+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: CC-BY-4.0 · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine