Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis

Marek Gogacz, Izabela Winkler, Agnieszka Bojarska-Junak, Agnieszka Bojarska−Junak, Jacek Tabarkiewicz, Andrzej Semczuk, Tomasz Rechberger, Aneta Adamiak
Journal of Reproductive Immunology · 2016 · vol. 117 , pp. 39–44 · doi:10.1016/j.jri.2016.04.289 · PMID:27371900 · W2399182235
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This study found that a higher proportion of Th17 cells in peritoneal fluid correlates with increased endometriosis severity.

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Abstract

AIM: Th17 cells are a newly discovered T helper lymphocyte subpopulation, producing interleukin IL-17. Th17 cells are present in blood and peritoneal fluid (PF) at different stages of endometriosis. We aim to establish their potential importance in the pathogenesis and clinical features of the disease. METHODS: The percentage of Th17 cells among T helper lymphocytes was determined in the PF and peripheral blood (PB) of patients with endometriosis and in the control group by flow cytometry using monoclonal antibodies: anti-CD-4-FITC, anti-CD-3-PE/Cy5, and anti-IL-17A-PE. RESULTS: Th17 percentage is increased in PF in comparison with PB in both endometriotic patients and in the control group. In severe endometriosis, the percentage of Th17 cells in PF was higher than with early (I/II stage) endometriosis. A positive correlation between the percentage of Th17 cells in PF and the white blood cell count in PB was found in patients with endometriosis. CONCLUSION: Targeting the activity of PF Th17 cells may have an influence on the proliferation of ectopic tissue and clinical manifestations of the disease.

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Condition tags

endometriosis

MeSH descriptors

Blood Cells Endometriosis Peritoneum Th17 Cells Adult Adult Blood Cells Blood Cells Cell Proliferation Cell Proliferation Cell Separation Cell Separation Disease Progression Disease Progression Endometriosis Endometriosis Female Female Flow Cytometry Flow Cytometry

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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