N-Acyl Dopamines Induce Apoptosis in Endometrial Stromal Cells from Patients with Endometriosis

Alina M. Gamisonia, M. N. Yushina, Marina N Yushina, Irina A Fedorova-Gogolina, Mikhail Akimov, Chupalav M Eldarov, Chupalav Eldarov, Stanislav V Pavlovich, С. В. Павлович, Vladimir V Bezuglov, В. В. Безуглов, N. M. Gretskaya, Natalia M Gretskaya, Gennady T Sukhikh, Г. Т. Сухих, М. Yu. Bobrov, Mikhail Yu Bobrov
International journal of molecular sciences · 2021 · vol. 22(19) , pp. 10648 · doi:10.3390/ijms221910648 · PMID:34638988 · W3204433841
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

N-acyl dopamines N-arachidonoyldopamine, N-docosahexaenoyldopamine, and N-oleoyldopamine selectively induced apoptosis in endometrial stromal cells from endometriosis patients via intrinsic pathway activation.

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Abstract

Endometriosis is characterized by the formation and development of endometrial tissues outside the uterus, based on an imbalance between proliferation and cell death, leading to the uncontrolled growth of ectopic foci. The potential target for the regulation of these processes is the endocannabinoid system, which was found to be involved in the migration, proliferation, and survival of tumor cells. In this paper, we investigated the effect of endocannabinoid-like compounds from the N-acyl dopamine (NADA) family on the viability of stromal cells from ectopic and eutopic endometrium of patients with ovarian endometriosis. N-arachidonoyldopamine, N-docosahexaenoyldopamine, and N-oleoyldopamine have been shown to have a five-times-more-selective cytotoxic effect on endometrioid stromal cells. To study the mechanisms of the toxic effect, inhibitory analysis, measurements of caspase-3/9 activity, reactive oxygen species, and the mitochondrial membrane potential were performed. It was found that NADA induced apoptosis via an intrinsic pathway through the CB1 receptor and downstream serine palmitoyltransferase, NO synthase activation, increased ROS production, and mitochondrial dysfunction. The higher selectivity of NADA for endometriotic stromal cells and the current lack of effective drug treatment can be considered positive factors for further research of these compounds as possible therapeutic agents against endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Apoptosis Arachidonic Acids Dopamine Endometriosis Endometrium Stromal Cells Apoptosis Arachidonic Acids Caspase 3 Caspase 3 Caspase 9 Caspase 9 Cells, Cultured Cell Survival Cell Survival Dopamine Dopamine Endometriosis Endometriosis Endometrium

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