С. В. Павлович

Objective. To study the correlation between structural characteristics, localization of deep infiltrating endometriosis (DIE) according to magnetic resonance imaging (MRI) and the severity of clinical symptoms, as well as to evaluate the di…

Endometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery. The pressing need for a timely, non-invasive diagnostic solution underscores the focus o…

Endometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery. The pressing need for a timely, non-invasive diagnostic solution underscores the focus o…

- 1 .., 1 .., 2 .., 1 .., 1 .., 3 .., 1 .., 1 .., 1,2 \ ..immunohistochemical method and evaluation of the H-score index.When the intensity of zinc finger E-box binding homeobox 1 staining in the endometrium was measured, it was revealed th…

Endometriosis affects about 10% of women of reproductive age and can negatively impact their quality of life (QoL). Due to the heterogeneity of symptoms or even their absence, early diagnosis is difficult. Therefore, it is necessary to comp…

Abstract: Endometriosis is a common gynecological condition characterized by the presence of endometrial-like tissue outside the uterus, causing chronic pelvic pain, dysmenorrhea, and infertility. Recent studies highlight the significant ro…

Aim. To study the regulation of apoptosis in the endometrium of women with chronic endometritis (CE) and external genital endometriosis (EGE) based on the study of the expression of its regulators such as transcription factor (NF-), Bcl-2 a…

The objective of the study was to evaluate the profile of serum autoantibodies and their diagnostic and pathogenetic significance in ovarian endometrioma (OEM) and deep infiltrative endometriosis (DIE). The study enrolled 74 patients with e…

Anti-Mullerian hormone (AMH) is well known as one of the key factors in reproductive development and the formation of sexual characteristics in the embryonic period in both sexes. In women, AMH is produced by granulosa cells of the preantra…

The aim of this study was to evaluate the levels of ten energy metabolism factors: C-peptide, ghrelin, GIP, GLP-1, glucagon, insulin, leptin, PAI-1 (total), resistin, and visfatin, and to determine the expression of GLP1R receptors, CD10, C…

A comparative analysis of the cell surface markers and immunological properties of cell cultures originating from normal endometrium and endometrioid heterotopias of women with extragenital endometriosis was carried out. Both types of cell …

Endometriosis is characterized by the formation and development of endometrial tissues outside the uterus, based on an imbalance between proliferation and cell death, leading to the uncontrolled growth of ectopic foci. The potential target …

The solution of many clinical problems, including the issues of the origin of pain as a component of individual pathologies, lies in the plane of quantitative objectification of the underlying disease and elucidation of the role of pain syn…

The review presents a critical analysis of data on the role of immune factors in the pathogenesis of endometriosis. The research results accumulated by now convincingly demonstrate that an abnormal subclinical inflammatory response and diso…

Endometriosis is a common estrogen-dependent chronic disease in women of reproductive age; it is associated with dysregulation of the immune response, local inflammation, and increased formation of autoantibodies. The aim of the study was t…

Endometriosis is a common estrogen-dependent chronic disease of women of reproductive age; it is associated with dysregulation of the immune response, local inflammatory process and increased autoantibody production. The purpose of this stu…

Concentrations of eight different cytokines and the level of CD86 and CD163 expression by macrophages were studied in the peritoneal fluid of women with endometriosis. The concentration of both pro-inflammatory (IL-6, IL-8, TNF-α) and anti-…

We performed a comparative study of the cytotoxic effect of endocannabinoid N-arachidonoyl dopamine (AA-DA) on cultured stromal cells of ectopic and eutopic endometrium. It was found that AA-DA in the concentration range of 1-20 μM produces…

Concentrations of eight different cytokines and the level of expression of CD86 and CD163 macrophages were studied in peritoneal fluid in women with endometriosis. It was found that the concentration of both inflammatory (IL-6, IL-8, TNF-α)…