IMMUNOHISTOCHEMICAL ANALYSIS OF EPITHELIAL-MESENCHIMAL TRANSITION MARKERS IN VARIOUS FORMS OF ENDOMETRIOSIS

- 1 .., 1 .., 2 .., 1 .., 1 .., 3 .., 1 .., 1 .., 1,2 \ ..immunohistochemical method and evaluation of the H-score index.When the intensity of zinc finger E-box binding homeobox 1 staining in the endometrium was measured, it was revealed that the level of expression in the group of patients with peritoneal endometriosis and deep infiltrative endometriosis was statistically significantly higher than in the control group.In samples of peritoneal heterotopias and deep infiltrating endometriosis, the expression level of zinc finger E-box binding homeobox 1 was also significantly increased compared to the results in the control group.Similar data were obtained when studying the expression of the zinc finger protein 1 and 2. Thus, increased levels of transcription factors of epithelial-mesenchymal transition in eutopic and ectopic endometrium indicate activation of the epithelial-mesenchymal transition process, which ensures the invasive potential of endometrioid heterotopias in endometriosis.