The role of anti-Mullerian hormone in the context of modern pathogenetic approaches to the treatment of endometriosis (literature review)

Н. А. Буралкина, N.A. Chekeneva, С. В. Павлович, V. D. Chuprynin, E. I. Pilyugina
In: Meditsinskiy sovet = Medical Council · 2023 · pp. 58–64 · doi:10.21518/ms2023-354 · W4387876715
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review explores anti-Mullerian hormone's role in endometriosis pathogenesis, highlighting its induction of apoptosis and autophagy in endometrial cells, suggesting therapeutic potential.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This literature review examines anti-Müllerian hormone (AMH) and its type II receptor AMHRII as potential pathogenetic links across gynecologic diseases, focusing on reproductive biology and proposed anti-tumor mechanisms. It describes evidence that AMH/AMHRII may contribute to endometriosis biology by inducing apoptosis of human endometrial stromal and endometriosis cells in vitro and by participating in autophagy processes, noting that AMHRII is expressed in ectopic and eutopic endometrial tissues as a possible target for therapy. A key limitation is that the paper synthesizes prior studies rather than presenting original experimental or clinical data, and it does not quantify effect sizes across studies. This paper is centrally about endometriosis — it specifically reviews AMH and AMHRII roles (including apoptosis, autophagy, and receptor targetability) in modern pathogenetic approaches to endometriosis treatment.

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Abstract

Anti-Mullerian hormone (AMH) is well known as one of the key factors in reproductive development and the formation of sexual characteristics in the embryonic period in both sexes. In women, AMH is produced by granulosa cells of the preantral and early antral follicles of the ovaries and is a key biochemical marker of ovarian reserve. Recently, the role of AMH and its transmembrane receptor AMHRII as possible pathogenetic links in a number of gynecological diseases has been actively studied. The ability of AMH to cause regression of the Müllerian duct in male embryos suggests its inhibitory role for a number of benign and malignant gynecological tumors, as well as endometriosis. In this connection, active scientific research in this direction is currently underway. A number of studies have shown that AMH causes apoptosis of human endometrial stromal cells and endometriosis cells in vitro, and is also involved in the development of autophagy processes in endometriosis. The above studies demonstrate the important role of AMH in cell apoptosis in endometriosis, and indicate its therapeutic potential for a wide range of gynecological diseases. It is important to note that AMH, as a representativemember of the TGF-β superfamily, has high affinity and specificity for the AMHRII receptor, which. This fact makes further study of the function of AMH and AMHRII relevant both for assessing their effectinfluence on the processes of folliculogenesis, and reproductive aging processes, and for developing new targeting targeted therapy strategies therapy for a wide range of gynecological diseases, including endometriosis.

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Condition tags

endometriosis

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