The expression of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor in myoma and adenomyosis

Shin Young Kim, Hye Min Moon, Min Kyoung Lee, Youn Jee Chung, Jae Yen Song, Hyun Hee Cho, Mee Ran Kim, Mee‐Ran Kim, Jang Heub Kim
Obstetrics & gynecology science · 2018 · vol. 61(1) , pp. 127 · doi:10.5468/ogs.2018.61.1.127 · PMID:29372159 · PMC5780307 · W2777327736
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Abstract

OBJECTIVE: We compared the expression levels of Müllerian inhibiting substance (MIS)/anti-Müllerian hormone type II receptor (AMHRII) in uterine myoma and adenomyosis to evaluate the possibility of using MIS/anti-Müllerian hormone (AMH) as a biological regulator or therapeutic agent in patients with uterine leiomyoma and adenomyosis. METHODS: We studied normal uterine myometrium, leiomyoma, endometrial tissue, and adenomyosis from 57 patients who underwent hysterectomy for uterine leiomyoma (22 cases) or adenomyosis (28 cases) and myomectomy for uterine myoma (7 cases). Immunohistochemical staining was used to confirm the MIS/AMHRII protein expression level in each tissue. Reverse transcription-polymerase chain reaction was performed to quantify MIS/AMHRII mRNA expression. RESULTS: The MIS/AMHRII protein was more strongly expressed in uterine myoma (frequency of MIS/AMHRII expressing cells: 51.95%±13.96%) and adenomyosis (64.65%±4.85%) tissues than that in the normal uterine myometrium (3.15%±1.69%) and endometrium (31.10%±7.19%). In the quantitative analysis of MIS/AMHRII mRNA expression, MIS/AMHRII mRNA expression levels in uterine myoma (mean density: 4.51±0.26) and adenomyosis (6.84±0.20) tissues were higher than that in normal uterine myometrial tissue (0.08±0.09) and endometrial tissue (1.63±0.06). CONCLUSION: This study demonstrated that MIS/AMHRII was highly and strongly expressed on uterine myoma and adenomyosis. Our data suggest that MIS/AMH may be evaluated as a biological modulator or therapeutic agent on MIS/AMHRII expressing uterine myoma and adenomyosis.

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adenomyosis

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chemicals 20
testosterone glycoprotein palmitoyl amino acid nitrogen diethyl 2-[(dimethoxyphosphoryl)thio]succinate water water agarose xylene alcohol diethylcarbamazine citrate polysorbate 20 biotin amino oligosaccharide haematoxylin levonorgestrel progestin danazol levonorgestrel levonorgestrel
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rabbits noordeloos 2009062 moloney murine leukemia virus isolate shinnick naine d'afrique de l'ouest rabbits human rabbits human human human

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