Expression of Müllerian Inhibiting Substance (MIS) and its receptor in female genital tract

Ham Bak Lee, Yoon Ji Jung, Min Jung Kim, Hyun Hee Cho, Mee‐Ran Kim, Eun Jung Kim, Jang Heub Kim
2013 · vol. 2(3) · W2098703567
article OA: closed CC0 ⤵ 1 in-corpus citation Metadata only
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This study found Mullerian inhibiting substance (MIS) expressed only in the ovary, while its receptor (MISRII) was present throughout the female genital tract with varying intensities.

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Abstract

Objective: Mullerian inhibiting Substance (MIS), also known as anti Mullerian hormone (AMH), is produced from Sertoli cells of fetal testis and it causes regression of Mullerian ducts. MIS is known to act as a regulator of female reproductive function but also inhibits the growth of Mullerian duct‐derived tumors in vivo and in vitro. But the physiologic role of MIS in female genital tract is not known clearly. Therefore, this study is aimed to confirm the expression of MIS and MISRII in female genital tract. Material and Methods: We gathered the tissues of female genital tract from the patients, who had the hysterectomy for benign uterine diseases like myoma uteri or adenomyosis. We divided the patients into follicular phase and luteal phase by menstrual cycle. We had undergone our experiment by using tissues from the ovary, uterine cervix, uterine endometrium, uterine myometrium and tube for each patient. We performed immune histochemistry and RT‐PCR to confirm MIS and MISRII in each tissues of female genital tract. Results: MIS was only expressed in ovarian tissue among the tissues of female genital tract. And MISRII was expressed in the entire female genital tract. But MISRII's expression intensity was different relatively. MISRII was very strongly expressed in ovary, and moderately expressed in uterine cervix, uterine endometrium, and fallopian tube. But MISRII was only mildly expressed in uterine myometrium with RT‐PCR. Conclusion: Finally we found that MIS is expressed only in ovary of female genital tract. And MISRII is presented on the entire female genital tract but the expression intensity was different relatively. These results suggest that MIS may have the function of biological modifier or inhibitor on female genital organ development and maturation. We could use this study for basic useful research to understand the physiology of MIS.

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