Expression of Annexin-1 in patients with endometriosis

Chun-yan Li, Chunyan Li, Jinghe Lang, Jing-he Lang, Hai-yuan Liu, Haiyuan Liu, Hui-mei Zhou, Huimei Zhou
Chinese medical journal · 2008 · vol. 121(10) , pp. 927–931 · doi:10.1097/00029330-200805020-00012 · PMID:18706208 · W37710874
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Annexin-1 mRNA and protein are overexpressed in eutopic endometrium and present in peritoneal fluids of endometriosis patients, potentially indicating its involvement in the disease's pathogenesis.

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Abstract

BACKGROUND: Annexin-1 was identified as an endometriosis-related protein by comparative proteomics in previous study. As an endogenous anti-inflammatory mediator, Annexin-1 has been shown to regulate the immune response, cell proliferation and apoptosis. To investigate whether Annexin-1 is involved in the pathogenesis of endometriosis, we examined the expression of Annexin-1 in eutopic endometrium of women with or without endometriosis, and detected its expression in peritoneal fluids of those with endometriosis. METHODS: Eutopic endometrium samples from twenty-five women with endometriosis and those from sixteen age-matched women without endometriosis were collected. Peritoneal fluids were obtained from ten patients with endometriosis. The expression of Annexin-1 protein in eutopic endometrium was detected by immunohistochemistry and Western blotting, and mRNA detected by real-time PCR. Annexin-1 protein in the peritoneal fluids was detected by Western blotting. RESULTS: Annexin-1 mRNA and protein were overexpressed in eutopic endometrium of endometriosis without significant differences between the proliferative and secretory phase. Immunohistochemistry showed that Annexin-1 protein was expressed mainly in endometrial glandular cells throughout the menstrual cycle. Annexin-1 protein was detected in the peritoneal fluids of all the ten patients with endometriosis. CONCLUSIONS: Annexin-1 is overexpressed in eutopic endometrium and presents in the peritoneal fluids of patients with endometriosis, and may play a role in the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Annexin A1 Endometriosis Adult Annexin A1 Annexin A1 Ascitic Fluid Ascitic Fluid Blotting, Western Endometriosis Endometriosis Endometriosis Female Gene Expression Humans Immunohistochemistry Middle Aged Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger RNA, Messenger RNA, Messenger

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