Pain in gynecology and neuroinflammation: the evil twin

Alessandra Graziottin, Stephen D. Skaper, Mariella Fusco, H San Raffaele Resnati
2014 · W2311929828
article OA: closed CC0 Metadata only
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Gynecological disorders associated with chronic pelvic pain exhibit neuroimmune dysregulation, primarily involving mast cells and nerve fibers, suggesting mast cell targeting as a therapeutic strategy.

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Abstract

There is increasing evidence that gynecological disorders associated to chronic pelvic pain (CPP) and co-morbid diseases are characterized by a neuroimmune dysregulation, involving mainly mast cells' (MC) distribution/function and nerve terminal fibers. MCs dysregulation might also promote spinal and supraspinal alterations associated with CPP. Collectively, these observations propose that a pharmacological strategy targeting MCs might represent an innovative strategy for the effective management of these disorders.

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chronic_pelvic_pain

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