Sleep disorders and hyperarousal among patients with endometriosis: A case-control survey study

Iannuzzo F, Fiammetta Iannuzzo, Simone Garzon, Lazzari C, Cecilia Lazzari, Irene Porcari, Porcari I, Mariachiara Bosco, Andrea Etrusco, Etrusco A, Laganà AS, Antonio Simone Laganà, Stefano Uccella, Uccella S, Chiantera V, Vito Chiantera, Vito Chiàntera, Celebre L, Laura Celebre, Mento C, Carmela Mento, Muscatello MRA, Maria Rosaria Anna Muscatello, Bruno A, Antonio Bruno
European journal of obstetrics, gynecology, and reproductive biology · 2024 · vol. 300 , pp. 287–295 · doi:10.1016/j.ejogrb.2024.07.031 · PMID:39053089 · W4400843025
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This case-control survey found that endometriosis patients report significantly higher levels of hyperarousal and sleep disturbances, with hyperarousal partially mediating the link between endometriosis and sleep issues.

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Abstract

BACKGROUND: Endometriosis has been associated with sleep disorders, and hyperarousal appears to be involved in their pathogenesis; however, the presence of hyperarousal in the endometriosis population was never investigated. METHODS: We conducted a case-control survey study by sending a questionnaire to all endometriosis patients followed up at our Centers. Controls were recruited among the general population. The questionnaire included demographic information, symptoms and history of endometriosis, the Hyperarousal Scale (H-Scale), the Pittsburgh Sleep Quality Index (PSQI), and the Insomnia Severity Index (ISI). RESULTS: A total of 847 women completed the questionnaires: 430 (50.8 %) had endometriosis, and 417 (49.2 %) were controls. Endometriosis was associated with higher H-scale score (OR 2.9, 95 % CI 2.4-3.8, p = 0.000), higher PSQI score (OR 4.3, 95 % CI 3.2-5.7, p = 0.000), and higher ISI score (OR 4.6, 95 % CI 3.5-6.1, p = 0.000) in multivariable ordinal logistic regressions analysis. With path analysis, hyperarousal (H-Scale) reported a partial mediating role in the association between endometriosis and sleep disorders. The mediation effect represented 22.3-27.8 % of the entire association between endometriosis and sleep disturbances. CONCLUSION: Endometriosis patients complaining sleep disorders may benefit by investigating the presence of hyperarousal given cognitive behavioral therapy was reported effective in improving hyperarousal and associated sleep disorders.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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