Laganà AS

Uterine fibroids (UFs) and endometrial polyps (EPs) are common benign gynecological conditions with distinct anatomical origins. However, their molecular impact on endometrial function remains poorly understood. This study aimed to descript…

This systematic review and meta-analysis (CRD42024588171) compared the effectiveness of surgery followed by IVF/intracytoplasmic sperm injection (IVF/ICSI) with direct IVF/ICSI (i.e. without previous surgery) on the reproductive outcomes of…

BACKGROUND: Poor ovarian response (POR) complicates a substantial proportion of in vitro fertilization (IVF) cycles, frequently causing cycle cancellation and suboptimal reproductive outcomes. Conventional follicular-phase ovarian stimulati…

OBJECTIVES: To update the 2021 International Society for Gynecologic Endoscopy (ISGE) recommendations for structured reporting of dynamic ultrasound findings in patients with suspected or known endometriosis, integrating recent technical an…

INTRODUCTION: Poor ovarian response (POR) remains a major limitation in assisted reproductive medicine. Direct comparisons between r-hFSH alfa + r-LH and r-hFSH delta + hMG in this population are scarce. METHODS: This retrospective study i…

PURPOSE: Despite various stimulation protocols and adjuvant treatments, optimizing the reproductive success of women with poor ovarian response (POR) undergoing assisted reproduction techniques (ART) remains a challenge. The aim was to eval…

BACKGROUND: To date, there are no clear guidelines available on the treatment of adenomyosis-associated pelvic pain (AAPP); however, numerous hormonal treatments (HTs) are currently being used off-label. We conducted a systematic review and…

BACKGROUND: Hormone pre-treatment is still used before assisted reproductive technique (ART) in endometriotic women, but evidence supporting this recommendation is conflicting. OBJECTIVES: To evaluate whether hormone pre-treatment with gon…

INTRODUCTION: Diaphragmatic endometriosis is considered the most common extrapelvic localization of endometriosis. Thoracic endometriosis syndrome (TES) involves endometriotic deposits in the pleura and lungs. Diaphragmatic endometriosis an…

OBJECTIVE: Endometriosis is a multifactorial disease that affects mainly women of reproductive age. It is unclear whether each form of pelvic endometriosis is an independent entity and whether a spatial relationship between all three endome…

Giuseppe Mascellino,1 Antonio Simone Laganà,1 Marco Anatrà,2 Pietro Serra,1 Giada Mesiano,3 Matteo Terrinoni,4,5 Vincenzo Mascellino,6 Simone Ferrero,2 Maurizio Serati,3 Maurizio Leone,2 Fabio Barra2,7 1Unit of Obstetrics and Gynecology, “P…

This manuscript presents a case of a 35-year-old nulligravida premenopausal woman who presented with acute abdominal pain due to pelvic congestion syndrome (PCS). PCS is characterized by multiple pathophysiological mechanisms and various cl…

In women with proven infertility and deep endometriosis (DE), optimal management is controversial. To date, there is no clear evidence on the association between infertility and different stages of rASRM, nor is there clear guidance from le…

BACKGROUND: Current evidence on the role of macro- and micronutrients in the aetiopathogenesis of endometriosis is controversial. OBJECTIVES: In this systematic review, we aimed to investigate the effect of macronutrients, dairy products, …

BACKGROUND: Endometriosis has been associated with sleep disorders, and hyperarousal appears to be involved in their pathogenesis; however, the presence of hyperarousal in the endometriosis population was never investigated. METHODS: We co…

Women with endometriosis were deemed more prone to COVID-19 infection in some reports. Considering that endometriosis-related aberrant immune response, understanding how COVID-19 vaccination influences its clinical status is crucial. The ai…

OBJECTIVES: The COVID-19 pandemic had adverse health outcomes on individuals and communities. In this cross-sectional study we evaluated the admission rates in a tertiary-level hospital during the first wave of the pandemic (March 22, 2020 …

Panagiotis Peitsidis,1 Panagiotis Tsikouras,2 Antonio Simone Laganà,3 Alexandros Laios,4 Ioannis D Gkegkes,5 Christos Iavazzo6 1Department of Obstetrics and Gynecology Helena Venizelou Hospital, Athens, Greece; 2Department of Obstetrics and…

Obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome is a rare congenital defect of the Müllerian ducts characterized by uterus didelphys, unilateral obstructed hemivagina, and ipsilateral renal agenesis. The aim of this s…

OBJECTIVE: The objective of the study was to develop a clinically applicable prediction tool to early seek for postoperative major complications after laparoscopic surgery for benign pathologies. DESIGN: Retrospective analysis of prospecti…