Causal associations between sleep disorders and endometriosis: A Mendelian randomization analysis

Xiaotian Yang, Yajie Qin, Huijin Zhao, Hongyan Zhao, Yi Zhou, Yuru Zhou, Huifang Zhou
Medicine · 2025 · vol. 104(45) , pp. e45786 · doi:10.1097/md.0000000000045786 · PMID:41204508 · W4416011132
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This Mendelian randomization study found genetic evidence that insomnia causally increases the risk of endometriosis, but other sleep traits did not show a causal link.

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Abstract

Evidence have indicated a correlation between sleep disorders and endometriosis, but the causal relationship remains uncertain. This study utilized Mendelian randomization (MR) approach to investigate the causal associations between sleep disorders and endometriosis. We conducted bidirectional 2-sample MR using inverse variance weighting as the primary analysis to assess forward and reverse causality. Multivariable Mendelian randomization were also utilized to adjust for confounders, reducing pleiotropy and residual confounding. Univariable MR analysis demonstrated a positive causal effect of insomnia on endometriosis (inverse variance weighting odds ratio: 2.021, 95% confidence interval: 1.280-3.192, P = .003). Multivariable Mendelian randomization analysis further confirmed that the robustness of the causal association between insomnia and endometriosis after adjusting for key confounders, such as body mass index, alcohol intake, smoking, and depression. However, no causal associations were detected between endometriosis and other sleep-related traits, including chronotype, sleep duration, daytime napping, and daytime sleepiness. This MR study gave novel genetic evidence supporting insomnia as an independent risk factor for endometriosis. These findings highlight the need for greater attention to endometriosis-related sleep disorders in both clinical practice and medical research.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (44)

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