Pathophysiological Changes in Early Endometriosis

Tao Zhang, Gene Chi Wai Man, Chi Chiu
In: Endometriosis - Basic Concepts and Current Research Trends · 2012 · doi:10.5772/31372 · W1607856287
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This paper describes the pathophysiology of early endometriosis, a common but poorly understood gynecological disorder first described in 1860.

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This review chapter examines the molecular and cellular mechanisms underlying the pathogenesis of early-stage endometriosis, focusing on inflammation, angiogenesis, and hormonal influences. It synthesizes existing literature to describe how ectopic endometrial-like tissue establishes itself in extrauterine locations through altered immune responses and genetic expression patterns. The authors highlight the role of oxidative stress and pro-inflammatory cytokines in promoting lesion survival and progression during the initial phases of disease development. This paper is centrally about endometriosis — specifically the pathophysiological changes that occur during its early stages.

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Abstract

Endometriosis is one of most common gynecological disorder, but poorly understood condition. As early as in 1860, von Rokitansky (Rokitansky, 1860) is the first one to describe www.intechopen.com
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Open access Submitted: 29 March 2011 Published: 09 May 2012 DOI: 10.5772/31372 From the Edited Volume Edited by Koel Chaudhury and Baidyanath Chakravarty Submitted: 29 March 2011 Published: 09 May 2012 © 2012 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Discover 2026 Nobel Laureate Francis Halzen’s chapter on IntechOpen >

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (79)

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last seen: 2026-06-10T17:14:06.276822+00:00
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