Systemic lupus erythematosus and reproductive function: a case-control study

D A Grimes, David A. Grimes, Grimes DA, LeBolt SA, S A LeBolt, Scot A. LeBolt, Grimes KR, Katherine R. Grimes, K R Grimes, P A Wingo, Phyllis A. Wingo, Wingo PA
American journal of obstetrics and gynecology · 1985 · vol. 153(2) , pp. 179–184 · doi:10.1016/0002-9378(85)90108-5 · PMID:4037012 · W2047592243
Observational OA: closed CC0 ⤵ 23 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This case-control study investigated the relationship between systemic lupus erythematosus and reproductive function.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Systemic lupus erythematosus characteristically afflicts women of reproductive age, yet the explanation for this feature is unknown. This hospital-based, case-control study of 109 incident cases of systemic lupus erythematosus and 109 randomly selected controls was conducted to search for risk factors related to reproduction. Women who were 34 years of age and younger had a crude risk of systemic lupus erythematosus 3.6 times that of older women, and women who were of minority races had a crude risk 4.8 times that of white women (P less than 0.001). Prior hysterectomy or tubal sterilization had a significant protective effect (odds ratio, 0.55; 95% confidence interval, 0.31 to 0.99). Endometriosis was associated with a twofold increased risk of systemic lupus erythematosus, although this was not statistically significant. The latter two findings are consistent with the hypothesis that retrograde menstruation may be an inciting factor for systemic lupus erythematosus in susceptible women.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Lupus Erythematosus, Systemic Reproduction Reproduction Adult Adult Aged Aged Age Factors Age Factors Disease Susceptibility Disease Susceptibility Endometriosis Endometriosis Endometriosis Epidemiologic Methods Epidemiologic Methods Female Female Georgia Georgia

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

Cited by (24)

Source provenance

europepmc
last seen: 2026-10-11T09:27:45.537177+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:49:28.095256+00:00
unpaywall
last seen: 2026-10-11T06:28:45.473802+00:00
License: CC0 · commercial use OK