Local danazol injection for treatment of unruptured tubal pregnancy (preliminary experience)
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This study reports preliminary experience with local danazol injection as a treatment for unruptured tubal pregnancy.
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Abstract
Fifteen women with unruptured tubal pregnancies diagnosed by laparoscopy and ultrasound were treated with danazol 400 mg, injected directly into the affected tube. Study inclusion criteria were (i) a rising or plateauing level of serum beta human chorionic gonadotropin (hCG), (ii) a tubal swelling less than 3 x 3 cm, (iii) an intact tubal serosa and (iv) no active bleeding. The women were monitored with serial measurements of beta-hCG. All women responded to a single danazol injection, no treatment failures were observed. After 3 months, hysterosalpinography revealed tubal pateny on the involved side in 14 patients and in 1 patient the tube was blocked. Within 1 year after danazol therapy patients were attempting to or had conceived. Of these, there were 3 intrauterine pregnancies and 2 recurrent contralateral pregnancies.
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Cites (2)
- Immunosuppressive effects of danazol in vitro 1987
- Preliminary observations on danazol therapy of systemic lupus erythematosus: effects on DNA antibodies, thrombocytopenia and complement. 1983
Cited by (1)
- Danazol 2022
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Cited by (1)
- Danazol 2022
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- last seen: 2026-05-11T05:53:22.067783+00:00
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