Expression of secretory leukocyte protease inhibitor in women with endometriosis

Nobuhiro Suzumori, Suzumori N, N Suzumori, Sato M, Makoto Sato, M Sato, Takunari Yoneda, T Yoneda, Yoneda T, Y Ozaki, Ozaki Y, Yasuhiko Ozaki, Takagi H, Hiroshi Takagi, H Takagi, K Suzumori, Kaoru Suzumori, Suzumori K
Fertility and sterility · 1999 · vol. 72(5) , pp. 857–867 · doi:10.1016/s0015-0282(99)00381-7 · PMID:10560990 · W1985192557
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This study investigated the presence and levels of secretory leukocyte protease inhibitor in women diagnosed with endometriosis.

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Abstract

ObjectiveTo explore endometriosis-related molecules in patients with use of differential display analysis.DesignProspective study.SettingNagoya City University Medical School, Nagoya, Japan.Patient(s)Women with endometriosis (n = 27) and without endometriosis (n = 21).Intervention(s)Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle.Main outcome measure(s)Differentially expressed products of endometrioma samples were sequenced at nucleotides. One of the candidate genes, secretory leukocyte protease inhibitor (SLPI) gene, was analyzed with use of in situ hybridization and Northern blot analyses. Distribution of SLPI was determined by immunohistochemistry, and the amount of SLPI in the peritoneal fluid and serum was measured by ELISA.Result(s)Distinct expression of SLPI messenger RNA could be detected in the endometrial-type epithelium of extrauterine endometriotic tissues and in the eutopic endometrium of women with endometriosis. SLPI was localized in the endometrial-type epithelium of endometriomas immunohistochemically. The amount of SLPI in the peritoneal fluid was markedly elevated in the endometriosis group (91.6+/-6.6 ng/mL compared with 68.4+/-5.3 ng/mL in the controls).Conclusion(s)Secretory leukocyte protease inhibitor may be involved in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gene Expression Regulation, Enzymologic Proteins Serine Proteinase Inhibitors Adult Ascitic Fluid Ascitic Fluid Blotting, Northern Case-Control Studies Endometriosis Gene Expression Regulation, Enzymologic Humans Immunohistochemistry In Situ Hybridization Middle Aged Proteinase Inhibitory Proteins, Secretory Proteins Reverse Transcriptase Polymerase Chain Reaction Secretory Leukocyte Peptidase Inhibitor Serine Proteinase Inhibitors

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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