Expression of secretory leukocyte protease inhibitor in women with endometriosis

Nobuhiro Suzumori, Suzumori N, N Suzumori, Sato M, Makoto Sato, M Sato, Takunari Yoneda, T Yoneda, Yoneda T, Y Ozaki, Ozaki Y, Yasuhiko Ozaki, Takagi H, Hiroshi Takagi, H Takagi, K Suzumori, Kaoru Suzumori, Suzumori K
Fertility and sterility · 1999 · vol. 72(5) , pp. 857–867 · doi:10.1016/s0015-0282(99)00381-7 · PMID:10560990 · W1985192557
Other OA: closed CC0 ⤵ 13 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated the presence and levels of secretory leukocyte protease inhibitor in women diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To explore endometriosis-related molecules in patients with use of differential display analysis. DESIGN: Prospective study. SETTING: Nagoya City University Medical School, Nagoya, Japan. PATIENT(S): Women with endometriosis (n = 27) and without endometriosis (n = 21). INTERVENTION(S): Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle. MAIN OUTCOME MEASURE(S): Differentially expressed products of endometrioma samples were sequenced at nucleotides. One of the candidate genes, secretory leukocyte protease inhibitor (SLPI) gene, was analyzed with use of in situ hybridization and Northern blot analyses. Distribution of SLPI was determined by immunohistochemistry, and the amount of SLPI in the peritoneal fluid and serum was measured by ELISA. RESULT(S): Distinct expression of SLPI messenger RNA could be detected in the endometrial-type epithelium of extrauterine endometriotic tissues and in the eutopic endometrium of women with endometriosis. SLPI was localized in the endometrial-type epithelium of endometriomas immunohistochemically. The amount of SLPI in the peritoneal fluid was markedly elevated in the endometriosis group (91.6+/-6.6 ng/mL compared with 68.4+/-5.3 ng/mL in the controls). CONCLUSION(S): Secretory leukocyte protease inhibitor may be involved in the pathogenesis of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Gene Expression Regulation, Enzymologic Proteins Serine Proteinase Inhibitors Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Blotting, Northern Blotting, Northern Case-Control Studies Case-Control Studies Endometriosis Endometriosis Gene Expression Regulation, Enzymologic Gene Expression Regulation, Enzymologic Humans Humans Immunohistochemistry

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (52)

Cited by (13)

Source provenance

europepmc
last seen: 2026-10-14T06:08:39.101224+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T20:59:14.592962+00:00
License: CC0 · commercial use OK