Research Article Endothelial nitric oxide synthase G894T polymorphism increases the risk of infertility in women with endometriosis

R.C.P.C. e Silva, Luciana Costa Faria, Kaylane Santos Silva, K.K.V.O. Moura, C.L. Ribeiro Júnior, Lídia Andreu Guillo
In: Genetics and Molecular Research · 2019 · vol. 18(2) · doi:10.4238/gmr18201 · W2948469075
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Abstract

Endometriosis is a chronic disease with adverse implications for fertility. We investigated the G894T polymorphism in the endothelial nitric oxide synthase gene in fertile and infertile women with endometriosis. This prospective study included a group of 52 women with a laparoscopic diagnosis of endometriosis. DNA was extracted from blood obtained from 47 patients and analyzed by PCR. The overall cohort was divided into infertile (n = 24) and fertile (n = 23) subgroups and compared in terms of genotypic and allelic frequencies. The genotypic distribution followed Hardy-Weinberg equilibrium ( 2 = 2.21, P = 0.137) and included the GG genotype in 28/47 GT in 14/47, and TT in 5/47 of the samples. Genotypic and allelic frequencies between fertile and infertile women with endometriosis showed that absence of the TT genotype was associated with fertility in endometriosis patients (P = 0.0623). The T R.C.P.C. e Silva et al. 2

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endometriosisinfertility

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