Higher IL-1beta level in the follicular liquid of endometriosis compared with non-endometriosis patients

Cahyono Hadi, Djaswadi Dasuki, Ahmad Hamim Sadewa, Indwiani Astuti, Awal Prasetyo
In: Majalah Obstetri & Ginekologi · 2020 · vol. 28(2) , pp. 59 · doi:10.20473/mog.v28i22020.59-66 · W3096525128
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Endometriosis patients showed significantly higher levels of IL-1beta in their follicular fluid compared to non-endometriosis patients.

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The study measured IL-1β levels in follicular fluid from 54 women diagnosed with endometriosis or without endometriosis based on ASRM criteria, using ELISA. IL-1β was higher in endometriosis patients (82.86 ± 30.15) than in non-endometriosis patients (56.05 ± 23.27; p=0.01), and the authors reported an ROC AUC of 59.3% with a stated cutoff around 26 in their analysis. A key caveat is that the reported discriminatory performance was modest, limiting how well IL-1β alone separated groups. This paper is centrally about endometriosis — it compares IL-1β concentrations in follicular fluid between endometriosis and non-endometriosis patients.

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Abstract

Objective: To ascertain the IL-1b level in the follicular liquid of endometriosis sufferers compared with that of non-endometriosis sufferers.Materials and Methods: The ELISA method, for detecting the IL-1b, is taken from follicular fluid of endometriosis as well as non-endometriosis patients that diagnosed according to the ASRM criteria.Results: The 54 subjects were dominantly endometriosis <34 year old (88.9%). The IL-1b levels of endometriosis patients and non-endometriosis patients were 82.86 ± 30.15 and 56.05 ± 23.27 respectively (p=0.01). The ROC value of IL-1b was found at a cut-off point of 26 (with the IL-1b cut-off point of 65.16). The discriminating value of AUC (area under curve) was 59.3%.Conclusion: It was concluded that the IL-1b level in endometriosis is higher than that in non- endometriosis.
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Objective

To ascertain the IL-1b level in the follicular liquid of endometriosis sufferers compared with that of non-endometriosis sufferers.

Materials and methods

The ELISA method, for detecting the IL-1b, is taken from follicular fluid of endometriosis as well as non-endometriosis patients that diagnosed according to the ASRM criteria.

Results

The 54 subjects were dominantly endometriosis <34 year old (88.9%). The IL-1b levels of endometriosis patients and non-endometriosis patients were 82.86 ± 30.15 and 56.05 ± 23.27 respectively (p=0.01). The ROC value of IL-1b was found at a cut-off point of 26 (with the IL-1b cut-off point of 65.16). The discriminating value of AUC (area under curve) was 59.3%.

Conclusion

It was concluded that the IL-1b level in endometriosis is higher than that in non- endometriosis.Amer S. Obstetrics, gynaecology and reproductive medicine. Endometriosis. 2008;18(5):126–33. Burney RO. Pathogenesis and pathophysiology of endometriosis', Fertility and Sterility. 2002;98(3): 511–9. Harada T and Iwabe T. Role of cytokines in endo-metriosis. Fertility and Ssterility. 2001;76(1): 1–10. Lebovic DI and Mueller MD. Immunobiology of endometriosis', Fertility and Sterility. 2001;76(1): 1–10. Alpay Z and Saed GM. Female infertility and free radicals: potential role in adhesions and endome-triosis. Journal of Society for Gynecologic Inves-tigation. 2006;13(6): 390–8. Gerald N, Caillaud M, Martoriati A, et al. The interleukin-1 system and female reproduction', The Journal of Endocrinology. 2004;180(2):203–12. Kim H, Ku SY, Kim SH et al. Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis. Human Reproduction. 2009;24(10):2656–9. Hadisaputra WPS. Serum biomarker profiles of interleukin-6, tumor necrosis factor alpha, matrix-metalloproteinase-2, and vascular edhothelial growth factor in endometriosis staging', Med J Indones. 2013;22(2):76–82. Gupta S, Agarwal A, Krajcir NA. Role of oxidative stress in endometriosis. Reprod Biomed Online. 2006;3(1):126–34. Pellicer A, Rubio C, Vidal F et al. In vitro fertil-ization plus preimplantation genetic diagnosis in patients with recurrent miscarriage: an analysis of chromosome abnormalities in human preimplant-ation embryos. Fertility and Sterility. 2009;71(6): 1033–9. Lucena E. Immune abnormalities in endometriosis compromising fertility in IVT-ET patients. The Journal of Reproductive Medicine. 2009;44(5): 458–64. Kyama CM, Overbergh L, Mihalyi A et al. Effect of recombinant human TNF-binding protein-1 and GnRH antagonist on mRNA expression of inflam-matory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons. Fertility and Sterility. 2008;89(5): 1306–13. Opí¸ien HK, Fedorcsak P, Omland AK et al. In vitro fertilization is a successful treatment in endo-metriosis-associated infertility. Fertility and Sterility. 2012;97(4), 912–8. 1. Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author. 2. The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/) 3. The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.

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endometriosis

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