Expression and Significance of miR-126 and miR-145 in Infertility due to Endometriosis

Cheng Fang, Cheng F, Fang Cheng, Luyan Lu, Lu L, Wang H, Huixia Wang, Hong Sheng Cheng, Cheng H, Hong Cheng, Dawei Zhang, Zhang D
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP · 2019 · vol. 29(6) , pp. 585–587 · doi:10.29271/jcpsp.2019.06.585 · PMID:31133163 · W2947086228
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Endometrial tissues from infertile women with endometriosis showed higher miR-126 and miR-145 expression compared to infertile controls, with elevated levels in non-pregnant versus pregnant patients.

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Abstract

The aim of this study was to determine the expression and significance of miR-126 and miR-145 in endometrial tissues in the mid-luteal phase of patients with infertility due to endometriosis. It was an experimental study carried out from January 2016 to July 2017. A total of 47 infertile patients with endometriosis were selected as an endometriosis group, and classified as 22 cases (46.81%) in stage I-II and 25 cases (53.19%) in stage III-IV; while 47 women who were infertile due to male factors were selected as a control group. The research showed that the expression levels of miR-126 and miR-145 in endometriosis group were higher than those of the control group (both p<0.001). There was no significant difference in the expression levels of miR-126 and miR-145 between the I-II and III-IV patients (p=0.535 and 0.809, respectively). The expression levels of miR-126 and miR-145 in endometrial tissues of non-pregnant patients were significantly higher than those of pregnant patients (both p<0.001). In conclusion, the up-regulated expression of miR-126 and miR-145 in the endometrial tissues in the mid-luteal phase of patients may play a role in infertility due to endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometrium Infertility, Female MicroRNAs Embryo Transfer Endometriosis Endometriosis Endometriosis Endometrium Female Fertilization in Vitro Humans Infertility, Female Infertility, Female Infertility, Female Luteal Phase MicroRNAs MicroRNAs Pregnancy Severity of Illness Index

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