Identification of potential repurposed drugs for treating endometriosis-associated infertility among women

Nayak R, Rojalin Nayak, Trisha Chattopadhyay, Bibekanand Mallick
Chemico-biological interactions · 2022 · vol. 365 , pp. 110110 · doi:10.1016/j.cbi.2022.110110 · PMID:35985520 · W4292087223
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This study identified potential repurposed drugs that could be used to treat endometriosis-associated infertility in women.

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Abstract

Endometriosis is the most common gynecological abnormality seen in 10-15% of women of reproductive age, causing infertility in ∼25% of cases, which calls for treatment. Thus, in this study, we have identified miRNAs and genes involved in endometriosis progression, leading to infertility, by performing gene expression analysis followed by pathway analysis and protein-protein networks study. Further, we have predicted repurposed small molecule drugs that will neutralize the regulatory effect of targeting miRNAs that induce sterility in endometriosis. This study predicted two transcription factors, FOXO1, and CREB1, targeted by miRNAs that can be modulated by the repurposed drugs, BRD-K55473186, and methylstat, respectively, for the treatment of infertility due to endometriosis. The former drug seems better and more effective than the other as it showed stronger binding at the active site of FOXO1. These findings provide the rationale for targeting miRNA-regulated transcriptional regulators controlling several biological processes to treat endometriosis and prevent the recurrence of implantation failure or infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (54)

Cited by (5)

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