Mizuguchi K

ORCID: 0000-0003-3021-7078 · 5 papers in corpus
article 2012
Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.11.005

ObjectiveTo determine the effect of dienogest (DNG) on the expression of aromatase and cyclooxygenase-2 (COX-2) and the production of prostaglandin E(2) (PGE(2)) in human endometriotic stromal cells (ESCs).DesignExperimental study in vitro.…

2011
TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery.
PloS one ·doi:10.1371/journal.pone.0017844

Prioritising candidate genes for further experimental characterisation is a non-trivial challenge in drug discovery and biomedical research in general. An integrated approach that combines results from multiple data types is best suited for…

article 2010
Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system
Steroids ·doi:10.1016/j.steroids.2010.08.010

Prostaglandin E(2) (PGE(2)) is a major mediator in the pathophysiology, and pathogenesis of gynecological diseases associated with abnormal endometrial disease with proliferation and inflammation, such as endometriosis. In this study, we in…

article 2009
Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression
Molecular human reproduction ·doi:10.1093/molehr/gap042

Dienogest is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. In this study, we examined the direct effects of dienogest on the proliferation of human endometrial …

2009
[Pharmacological and clinical profile of dienogest (DINAGEST Tab. 1 mg)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica ·doi:10.1254/fpj.133.32