A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis

Luigi Cobellis, Cobellis L, Razzi S, Sandro Razzi, Antonio Fava, Fava A, Filiberto M Severi, Filiberto Maria Severi, Igarashi M, Masao Igarashi, Felice Petraglia
Fertility and sterility · 2004 · vol. 82(1) , pp. 239–240 · doi:10.1016/j.fertnstert.2003.11.058 · PMID:15237024 · W2007073683
Non-randomised trial OA: closed CC0 ⤵ 53 in-corpus citations
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A danazol-loaded intrauterine device effectively reduced dysmenorrhea, pelvic pain, and dyspareunia in patients diagnosed with endometriosis.

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Abstract

A danazol-loaded intrauterine device (IUD) containing 300-400 mg of danazol was inserted for 6 months in a group of women (n = 18) (median age 36.6 years; age range: 30 to 46 years) with a histologic diagnosis of endometriosis, referred for recurrent pelvic pain. Dysmenorrhea, dyspareunia, and pelvic pain significantly decreased after the first month, with a persistent effect during the 6 months of IUD insertion. These results show that a danazol-loaded IUD is an effective conservative therapy for patients with endometriosis-related pelvic pain.

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Condition tags

dysmenorrheadyspareuniaendometriosis

MeSH descriptors

Danazol Dysmenorrhea Dyspareunia Endometriosis Estrogen Antagonists Intrauterine Devices, Medicated Intrauterine Devices, Medicated Adult Adult Danazol Danazol Dysmenorrhea Dysmenorrhea Dysmenorrhea Dyspareunia Dyspareunia Dyspareunia Endometriosis Endometriosis Estrogen Antagonists

Citation neighborhood (2-hop)

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References (8)

Cited by (50)

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