Management of Endometriosis-associated Pain

Keith A. Hansen, Hansen KA, Abha J. Chalpe, Chalpe A, Abha Chalpe, Eyster KM, Kathleen M. Eyster
Clinical Obstetrics and Gynecology · 2010 · vol. 53(2) , pp. 439–448 · doi:10.1097/grf.0b013e3181dbda06 · PMID:20436321 · W2041525156
article OA: closed CC0 ⤵ 21 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

Endometriosis-associated pain in reproductive-age females is managed with conservative surgery, radical hysterectomy for completed childbearing, or medical therapies that interrupt ovarian hormone production.

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This review examines the management strategies for pain associated with endometriosis, a prevalent condition causing morbidity in reproductive-age women. It outlines conservative surgical options that preserve fertility alongside radical approaches like hysterectomy for those who have completed childbearing, while noting that medical therapies function by suppressing ovarian hormone production to inhibit lesion growth. The authors also highlight the potential of genomics to refine future treatments based on individual symptoms and reproductive goals. This paper is centrally about endometriosis — specifically focusing on the surgical and medical management of pain associated with the disease.

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Abstract

Endometriosis, a common cause of morbidity in reproductive-age females, results in pelvic pain and infertility. Endometriosis-associated pain can be approached with surgical or medical therapies. Conservative surgery maintains reproductive organs and is effective in the treatment of endometriosis-associated pain. A more radical surgical approach of hysterectomy with bilateral salpingo-oophorectomy remains a mainstay of therapy for patients who have completed childbearing. Current medical therapies rely upon interruption of normal cyclic ovarian hormone production resulting in an environment not conducive to the growth of endometriosis. Genomics promises to further characterize endometriosis and tailor therapies based on a woman's symptoms and reproductive goals.
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Management of Endometriosis-associated Pain - KEITH A. HANSEN - ABHA CHALPE - KATHLEEN M. EYSTER Endometriosis, a common cause of morbidity in reproductive-age females, results in pelvic pain and infertility. Endometriosis-associated pain can be approached with surgical or medical therapies. Conservative surgery maintains reproductive organs and is effective in the treatment of endometriosis-associated pain. A more radical surgical approach of hysterectomy with bilateral salpingo-oophorectomy remains a mainstay of therapy for patients who have completed childbearing. Current medical therapies rely upon interruption of normal cyclic ovarian hormone production resulting in an environment not conducive to the growth of endometriosis. Genomics promises to further characterize endometriosis and tailor therapies based on a woman's symptoms and reproductive goals.

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Condition tags

endometriosischronic_pelvic_paininfertility

MeSH descriptors

Aromatase Inhibitors Danazol Endometriosis Laparoscopy Pelvic Pain Aromatase Inhibitors Combined Modality Therapy Contraceptives, Oral Contraceptives, Oral Danazol Endometriosis Endometriosis Endometriosis Evidence-Based Medicine Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Hysterectomy Hysterectomy

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References (41)

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