Correlation of changes of (non)exfoliated endometrial organelles and expressions of Musashi-1 and β-catenin with endometriosis in menstrual period

Yu CX, Cong-Xiang Yu, Song JH, Jinghui Song, Jing-Hui Song, Lei Liang, Liang L
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2014 · vol. 30(12) , pp. 861–867 · doi:10.3109/09513590.2014.955467 · PMID:25162724 · W2030092295
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Endometrial organelle structural changes and increased Msi-1 and β-catenin expression correlated with endometriosis, suggesting Msi-1 activation of the Wnt/β-catenin pathway may contribute to its formation.

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Abstract

This study aims to investigate the correlation of structural changes of endometrial organelles and expressions of Musashi-1 (Msi-1) and β-catenin with the endometriosis (EMs) in the menstrual period. The structural changes of exfoliated and nonexfoliated endometrial organelles in the experimental group and the control group were observed by the transmission electron microscopy (TEM) on the first and fifth day of menstruation. (1) TEM: compared with the control group, the exfoliated endometrial organelles in the experimental group on the first day were rich, with irregular nucleus, the bi-nucleolus could be seen, with rich chromatin; while the shapes of epithelial secretory cells in the nonexfoliated endometrial gland were irregular, with abundant organelles, the basal film varied in width, with abnormal curvature, and a lot of intercellular collagen fibers could be seen. (2) The expressions of Msi-1 and β-catenin in the exfoliated and nonexfoliated endometrium of the experimental group were higher than those of the control group and exhibited positively correlation, while no correlation could be found within the control group. (1) The organelles' structural changes might cause the changes of endometrial cellular functions. (2) Msi-1 might participate in the formation of EMs through activating the Wnt/β-catenin signaling pathway.

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Condition tags

endometriosis

MeSH descriptors

beta Catenin Endometriosis Endometrium Menstruation Nerve Tissue Proteins Organelles RNA-Binding Proteins Adult beta Catenin Endometriosis Endometrium Epithelial Cells Epithelial Cells Female Humans Menstruation Nerve Tissue Proteins Organelles RNA-Binding Proteins Signal Transduction

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