Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis

Yang JH, Jehn-Hsiahn Yang, Jehn‐Hsiahn Yang, Mei-Jou Chen, Chen MJ, Mei‐Jou Chen, Ming-Yih Wu, Ming‐Yih Wu, Chen YC, Yi-Chun Chen, Yi‐Chun Chen, Yu-Shih Yang, Yu‐Shih Yang, Yang YS, Hong‐Nerng Ho, Hong-Nerng Ho
Fertility and sterility · 2006 · vol. 86(5) , pp. 1459–1465 · doi:10.1016/j.fertnstert.2006.04.034 · PMID:16989825 · W2033949045
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Medroxyprogesterone acetate and danazol treatments failed to restore normal interleukin-6 suppression in endometrial stromal cells from women with adenomyosis.

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Abstract

ObjectiveTo examine changes in local cytokine production in the eutopic endometrium of adenomyosis after treatment with medroxyprogesterone acetate (MPA) and danazol.DesignProspective cohort study.SettingTertiary university hospital.Patient(s)Twenty-four women with adenomyosis (study group) and 22 women without adenomyosis (control group).Intervention(s)Eutopic endometrium was separated into single endometrial stromal cells (ESCs), and was cultured in vitro alone, with MPA (10(-7) M), or with danazol (10(-7) M) for 8 days.Main outcome measure(s)Messenger RNA expression of interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha in ESCs, and their concentrations in the supernatants of ESCs.Result(s)A significant decrease of IL-6 concentration in the supernatant, measured by ELISA, was found with time of ESCs cultured with MPA and danazol in the control group, but not in adenomyosis. The IL-6 mRNA in ESCs determined by real-time quantitative polymerase chain, as well as its concentration in the supernatant, was much higher in adenomyosis than that in the control group after treatment with MPA and danazol for 8 days.Conclusion(s)Medroxyprogesterone acetate and danazol appeared to have a decreased effect on the suppression of IL-6 liberated by ESCs in adenomyosis. This aberrant secretion of IL-6 might play a role in the formation of ectopic endometrial implants in adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Danazol Endometriosis Endometrium Interleukin-6 Medroxyprogesterone Acetate Stromal Cells Uterine Diseases Cells, Cultured Cohort Studies Contraceptive Agents, Female Contraceptive Agents, Female Danazol Drug Combinations Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estrogen Antagonists

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